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Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination.
Fuenfgeld, Brigitte; Mächler, Philipp; Fischer, Dorothee R; Esposito, Giuseppe; Rushing, Elisabeth Jane; Kaufmann, Philipp A; Stolzmann, Paul; Huellner, Martin W.
Afiliación
  • Fuenfgeld B; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
  • Mächler P; University of Zurich, Zurich, Switzerland.
  • Fischer DR; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
  • Esposito G; Department of Radiology and Nuclear Medicine, Hospital St. Anna, Lucerne, Switzerland.
  • Rushing EJ; Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.
  • Kaufmann PA; University of Zurich, Zurich, Switzerland.
  • Stolzmann P; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland.
  • Huellner MW; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
PLoS One ; 15(4): e0230618, 2020.
Article en En | MEDLINE | ID: mdl-32302317
PURPOSE: The aim of this study was to derive reference values of 18F-fluoro-ethyl-L-tyrosine positron emission tomography (18F-FET-PET) uptake in normal brain and head structures to allow for differentiation from tumor tissue. MATERIALS AND METHODS: We examined the datasets of 70 patients (median age 53 years, range 15-79), whose dynamic 18F-FET-PET was acquired between January 2016 and October 2017. Maximum standardized uptake value (SUVmax), target-to-background standardized uptake value ratio (TBR), and time activity curve (TAC) of the 18F-FET-PET were assessed in tumor tissue and in eight normal anatomic structures and compared using the t-test and Mann-Whitney U-test. Correlation analyses were performed using Pearson or Spearman coefficients, and comparisons between several variables with Pearson's chi-squared tests and Kruskal-Wallis tests as well as the Benjamini-Hochberg correction. RESULTS: All analyzed structures showed an 18F-FET uptake higher than background (threshold: TBR > 1.5). The venous sinuses and cranial muscles exhibited a TBR of 2.03±0.46 (confidence interval (CI) 1.92-2.14), higher than the uptake of caudate nucleus, pineal gland, putamen, and thalamus (TBR 1.42±0.17, CI 1.38-1.47). SUVmax, TBR, and TAC showed no difference in the analyzed structures between subjects with high-grade gliomas and subjects with low-grade gliomas, except the SUVmax of the pineal gland (t-tests of the pineal gland: SUVmax: p = 0.022; TBR: p = 0.411). No significant differences were found for gender and age. CONCLUSION: Normal brain tissue demonstrates increased 18F-FET uptake compared to background tissue. Two distinct clusters have been identified, comprising venous structures and gray matter with a reference uptake of up to SUVmax of 2.99 and 2.33, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirosina / Neoplasias Encefálicas / Tomografía de Emisión de Positrones Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirosina / Neoplasias Encefálicas / Tomografía de Emisión de Positrones Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos