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Epidemiology of hospitalised paediatric community-acquired pneumonia and bacterial pneumonia following the introduction of 13-valent pneumococcal conjugate vaccine in the national immunisation programme in Japan.
Takeuchi, N; Naito, S; Ohkusu, M; Abe, K; Shizuno, K; Takahashi, Y; Omata, Y; Nakazawa, T; Takeshita, K; Hishiki, H; Hoshino, T; Sato, Y; Ishiwada, N.
Afiliación
  • Takeuchi N; Department of Infectious Diseases, Medical Mycology Research Centre, Chiba University, Chiba, Japan.
  • Naito S; Department of Paediatrics, Chiba University Hospital, Chiba, Japan.
  • Ohkusu M; Department of Infectious Diseases, Medical Mycology Research Centre, Chiba University, Chiba, Japan.
  • Abe K; Department of Paediatrics, Chiba Kaihin Municipal Hospital, Chiba, Japan.
  • Shizuno K; Department of Clinical Laboratory, Chiba Kaihin Municipal Hospital, Chiba, Japan.
  • Takahashi Y; Department of Paediatrics, Seikeikai Chiba Medical Centre, Chiba, Japan.
  • Omata Y; Department of Paediatrics, Seikeikai Chiba Medical Centre, Chiba, Japan.
  • Nakazawa T; Department of Paediatrics, Seikeikai Chiba Medical Centre, Chiba, Japan.
  • Takeshita K; Department of Paediatrics, Chiba University Hospital, Chiba, Japan.
  • Hishiki H; Department of Paediatrics, Chiba University Hospital, Chiba, Japan.
  • Hoshino T; Division of Infectious Diseases, Chiba Children's Hospital, Chiba, Japan.
  • Sato Y; Department of Preventive Medicine and Public Health, Keio University School of Medicine, Shinjuku-ku, Japan.
  • Ishiwada N; Department of Infectious Diseases, Medical Mycology Research Centre, Chiba University, Chiba, Japan.
Epidemiol Infect ; 148: e91, 2020 04 17.
Article en En | MEDLINE | ID: mdl-32299523
Studies on community-acquired pneumonia (CAP) and pneumococcal pneumonia (PP) related to the 13-valent pneumococcal conjugate vaccine (PCV13) introduction in Asia are scarce. This study aimed to investigate the epidemiological and microbiological determinants of hospitalised CAP and PP after PCV13 was introduced in Japan. This observational hospital-based surveillance study included children aged ⩽15 years, admitted to hospitals in and around Chiba City, Japan. Participants had bacterial pneumonia based on a positive blood or sputum culture for bacterial pathogens. Serotype and antibiotic-susceptibility testing of Streptococcus pneumoniae and Haemophilus influenzae isolates from patients with bacterial pneumonia were assessed. The CAP hospitalisation rate per 1000 child-years was 17.7, 14.3 and 9.7 in children aged <5 years and 1.18, 2.64 and 0.69 in children aged 5-15 years in 2008, 2012 and 2018, respectively. There was a 45% and 41% reduction in CAP hospitalisation rates, between the pre-PCV7 and PCV13 periods, respectively. Significant reductions occurred in the proportion of CAP due to PP and PCV13 serotypes. Conversely, no change occurred in the proportion of CAP caused by H. influenzae. The incidence of hospitalised CAP in children aged ⩽15 years was significantly reduced after the introduction of PCV13 in Japan. Continuous surveillance is necessary to detect emerging PP serotypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Neumocócica / Programas de Inmunización / Infecciones Comunitarias Adquiridas / Vacunas Neumococicas Tipo de estudio: Screening_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Epidemiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Neumocócica / Programas de Inmunización / Infecciones Comunitarias Adquiridas / Vacunas Neumococicas Tipo de estudio: Screening_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Epidemiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido