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Multifaceted Role of PRDM Proteins in Human Cancer.
Casamassimi, Amelia; Rienzo, Monica; Di Zazzo, Erika; Sorrentino, Anna; Fiore, Donatella; Proto, Maria Chiara; Moncharmont, Bruno; Gazzerro, Patrizia; Bifulco, Maurizio; Abbondanza, Ciro.
Afiliación
  • Casamassimi A; Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio, 80138 Naples, Italy.
  • Rienzo M; Department of Environmental, Biological, and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
  • Di Zazzo E; Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio, 80138 Naples, Italy.
  • Sorrentino A; Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.
  • Fiore D; Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio, 80138 Naples, Italy.
  • Proto MC; Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy.
  • Moncharmont B; Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy.
  • Gazzerro P; Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.
  • Bifulco M; Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy.
  • Abbondanza C; Department of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", 80131 Naples, Italy.
Int J Mol Sci ; 21(7)2020 Apr 10.
Article en En | MEDLINE | ID: mdl-32290321
The PR/SET domain family (PRDM) comprise a family of genes whose protein products share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1)] homologous domain structurally and functionally similar to the catalytic SET [Su(var)3-9, enhancer-of-zeste and trithorax] domain of histone methyltransferases (HMTs). These genes are involved in epigenetic regulation of gene expression through their intrinsic HMTase activity or via interactions with other chromatin modifying enzymes. In this way they control a broad spectrum of biological processes, including proliferation and differentiation control, cell cycle progression, and maintenance of immune cell homeostasis. In cancer, tumor-specific dysfunctions of PRDM genes alter their expression by genetic and/or epigenetic modifications. A common characteristic of most PRDM genes is to encode for two main molecular variants with or without the PR domain. They are generated by either alternative splicing or alternative use of different promoters and play opposite roles, particularly in cancer where their imbalance can be often observed. In this scenario, PRDM proteins are involved in cancer onset, invasion, and metastasis and their altered expression is related to poor prognosis and clinical outcome. These functions strongly suggest their potential use in cancer management as diagnostic or prognostic tools and as new targets of therapeutic intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / N-Metiltransferasa de Histona-Lisina / Proteínas de Unión al ADN / Factor 1 de Unión al Dominio 1 de Regulación Positiva / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / N-Metiltransferasa de Histona-Lisina / Proteínas de Unión al ADN / Factor 1 de Unión al Dominio 1 de Regulación Positiva / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza