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The newly proposed International Endocervical Adenocarcinoma Criteria and Classification and its relevance to cervical cytology screening assessed in a prospective 2-year study of 118 cases.
Ondic, Ondrej; Nemcová, Jana; Alaghehbandan, Reza; Cerná, Katerina; Gomolcáková, Barbora; Kinkorová-Lunácková, Iva; Chytra, Jan; Sidlová, Henrieta; Hósová, Marta; Bouda, Jirí.
Afiliación
  • Ondic O; Department of Pathology, Medical Faculty, Charles University Hospital Pilsen, Charles University, Pilsen, Czech Republic.
  • Nemcová J; Bioptická laborator, s.r.o., Pilsen, Czech Republic.
  • Alaghehbandan R; Department of Pathology, Medical Faculty, Charles University Hospital Pilsen, Charles University, Pilsen, Czech Republic.
  • Cerná K; Bioptická laborator, s.r.o., Pilsen, Czech Republic.
  • Gomolcáková B; Department of Pathology, Royal Columbian Hospital, University of British Columbia, Vancouver, BC, Canada.
  • Kinkorová-Lunácková I; Department of Pathology, Medical Faculty, Charles University Hospital Pilsen, Charles University, Pilsen, Czech Republic.
  • Chytra J; Bioptická laborator, s.r.o., Pilsen, Czech Republic.
  • Sidlová H; Bioptická laborator, s.r.o., Pilsen, Czech Republic.
  • Hósová M; Bioptická laborator, s.r.o., Pilsen, Czech Republic.
  • Bouda J; Department of Gynecology and Obstetrics, Medical Faculty, Charles University Hospital Pilsen, Charles University, Pilsen, Czech Republic.
Cytopathology ; 31(4): 288-291, 2020 07.
Article en En | MEDLINE | ID: mdl-32289186
BACKGROUND: It is generally acknowledged that interobserver variability for the histological diagnosis of endocervical adenocarcinoma (EA) subtypes is suboptimal. The recently proposed International Endocervical Adenocarcinoma Criteria and Classification (IECC) system is based on the presence of associated human papilloma virus (HPV) infection. It recognises HPV-associated EAs and non-HPV-associated EAs. METHODS: This prospective cytology-histology and molecular genetics-based study investigated the potential effect of IECC being applied to Papanicolaou (Pap) test with regard to the diagnostic accuracy of severe glandular lesions reported at least as adenocarcinoma in situ (AIS). RESULTS: Out of 118 liquid-based cytology Pap tests with AIS+ lesion, complete information on follow-up biopsy and HPV status was available in 51 cases. AIS and EA category correlated with histologically confirmed AIS/EA in 88.5% (23/26) and 70.5% (12/17) of cases, respectively. Interestingly, 93% (40/43) of cases diagnosed as AIS/EA were HPV positive and 7% (3/43) were HPV negative (originating in the cervix, endometrium and adnexa). CONCLUSIONS: Our findings suggest that this approach could possibly divide Pap tests containing severe glandular lesion into two groups: (a) robust diagnosis of HPV-associated EA and (b) non-HPV associated glandular lesions of heterogeneous origin, requiring further clinical preoperative diagnostic workup.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Displasia del Cuello del Útero / Infecciones por Papillomavirus / Detección Precoz del Cáncer Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Cytopathology Asunto de la revista: PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Displasia del Cuello del Útero / Infecciones por Papillomavirus / Detección Precoz del Cáncer Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Cytopathology Asunto de la revista: PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Reino Unido