OBJECTIVE: The aim: Efficacy assessment of herpesvirus infection drug prophylaxis (HVI) manifestations in the mouth of patients with chronic herpes-associated generalized periodontitis (CHGP) of moderate severity during and shortly after closed curettage. PATIENTS AND METHODS: Materials and methods: The total of 87 patients with CHGP of moderate severity aged 35-60 years were examined and divided into groups according to the presence of HVI: Group I (main) included 48 patients who had herpesvirus infection; group II (comparison) - 39 patients who were not found herpesvirus infection. Group III was formed based on the data of out-patient medical reports retrospective analysis and was used to compare the number of complication cases. The control group included 20 patients with intact periodontium. Prior to treatment, patients in group I, was additionally assigned multicomponent phytocomplex. The treatment efficacy was assessed by the concentration dynamics of A, G, M immunoglobulins, circulating immune complexes (CIC) and sIgA, hygienic and periodontal indices, as well as by the dynamics of gum fluid and the recovery terms. RESULTS: Results: The study on the dynamics of clinical indices and some humoral immunity indices confirmed the main group patients after closed curettage had positive shifts in sIgA, IgA, IgG, IgM and CIC levels. Their indices did not have a statistically significant difference with similar indicators of the comparison group. In group I, complications in the form of HVI manifestations in the buccal mucous membrane (BMM) were found in 8.33% of patients, which had a statistically significant difference (p <0.001) from the percentage of patients with HVI, with complications in group III (35.71% ). The recovery terms for patients in group I were by 16.7% shorter than the similar terms in group III. CONCLUSION: Conclusions: The results obtained indicate that the phytocomplex used by us can be applied as an immunomodulatory agent for the prevention of herpes virus infection manifestations in the oral cavity of patients with interventions in BMM and periodontal tissues.