Symmetrically substituted dichlorophenes inhibit <i>N</i>-acyl-phosphatidylethanolamine phospholipase D.

Aggarwal, Geetika; Zarrow, Jonah E; Mashhadi, Zahra; Flynn, C Robb; Vinson, Paige; Weaver, C David; Davies, Sean S

Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D.

Aggarwal, Geetika; Zarrow, Jonah E; Mashhadi, Zahra; Flynn, C Robb; Vinson, Paige; Weaver, C David; Davies, Sean S.

Afiliación

Aggarwal G; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Zarrow JE; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Mashhadi Z; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Flynn CR; Division of Surgery, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
Vinson P; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232.
Weaver CD; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232.
Davies SS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232. Ele

J Biol Chem ; 295(21): 7289-7300, 2020 05 22.

Article en En | MEDLINE | ID: mdl-32284327

Asunto(s)

Diclorofeno; Inhibidores Enzimáticos; Fosfolipasa D; Animales; Proteínas Bacterianas/antagonistas & inhibidores; Proteínas Bacterianas/química; Proteínas Bacterianas/metabolismo; Bitionol/química; Bitionol/farmacología; Diclorofeno/química; Diclorofeno/farmacología; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/farmacología; Células HEK293; Hexaclorofeno/química; Hexaclorofeno/farmacología; Humanos; Ratones; Fosfolipasa D/antagonistas & inhibidores; Fosfolipasa D/química; Fosfolipasa D/metabolismo; Quinazolinas/química; Quinazolinas/farmacología; Streptomyces/enzimología; Sulfonamidas/química; Sulfonamidas/farmacología

Palabras clave

N-acyl-ethanolamide; N-acyl-phosphatidylethanolamine; NAPE-PLD; TGR5; bile acid; dichlorophene; endocannabinoid; high-throughput screening (HTS); lipid signaling; metabolic disease; phospholipase D; proteinlipid interaction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfolipasa D / Diclorofeno / Inhibidores Enzimáticos Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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