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Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3ß and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease.
Thota, Rohith N; Rosato, Jessica I; Dias, Cintia B; Burrows, Tracy L; Martins, Ralph N; Garg, Manohar L.
Afiliación
  • Thota RN; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Rosato JI; Riddet Institute, Massey University, Palmerston North 4474, New Zealand.
  • Dias CB; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Burrows TL; School of Health Sciences, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Martins RN; Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Garg ML; School of Biomedical Sciences, Macquarie University, Macquarie, NSW 2109, Australia.
Nutrients ; 12(4)2020 Apr 09.
Article en En | MEDLINE | ID: mdl-32283762
Dietary supplementation with curcumin has been previously reported to have beneficial effects in people with insulin resistance, type 2 diabetes (T2D) and Alzheimer's disease (AD). This study investigated the effects of dietary supplementation with curcumin on key peptides implicated in insulin resistance in individuals with high risk of developing T2D. Plasma samples from participants recruited for a randomised controlled trial with curcumin (180 mg/day) for 12 weeks were analysed for circulating glycogen synthase kinase-3 ß (GSK-3ß) and islet amyloid polypeptide (IAPP). Outcome measures were determined using ELISA kits. The homeostasis model for assessment of insulin resistance (HOMA-IR) was measured as parameters of glycaemic control. Curcumin supplementation significantly reduced circulating GSK-3ß (-2.4 ± 0.4 ng/mL vs. -0.3 ± 0.6, p = 0.0068) and IAPP (-2.0 ± 0.7 ng/mL vs. 0.4 ± 0.6, p = 0.0163) levels compared with the placebo group. Curcumin supplementation significantly reduced insulin resistance (-0.3 ± 0.1 vs. 0.01 ± 0.05, p = 0.0142) compared with placebo group. Dietary supplementation with curcumin reduced circulating levels of IAPP and GSK-3ß, thus suggesting a novel mechanism through which curcumin could potentially be used for alleviating insulin resistance related markers for reducing the risk of T2D and AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Suplementos Dietéticos / Curcumina / Diabetes Mellitus Tipo 2 / Polipéptido Amiloide de los Islotes Pancreáticos / Enfermedad de Alzheimer / Glucógeno Sintasa Quinasa 3 beta Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Suplementos Dietéticos / Curcumina / Diabetes Mellitus Tipo 2 / Polipéptido Amiloide de los Islotes Pancreáticos / Enfermedad de Alzheimer / Glucógeno Sintasa Quinasa 3 beta Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza