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Secondary metabolites from Verbascum bugulifolium Lam. and their bioactivities.
Gökmen, Ayse; Kúsz, Norbert; Karaca, Nursenem; Demirci, Fatih; Hohmann, Judit; Kirmizibekmez, Hasan.
Afiliación
  • Gökmen A; Faculty of Pharmacy, Department of Pharmacognosy, Yeditepe University, Istanbul, Turkey.
  • Kúsz N; Faculty of Pharmacy, Department of Pharmacognosy, University of Szeged, Szeged, Hungary.
  • Karaca N; Department of Pharmacognosy, Graduate School of Health Sciences, Anadolu University, Eskisehir, Turkey.
  • Demirci F; Faculty of Pharmacy, Department of Pharmacognosy, Anadolu University, Eskisehir, Turkey.
  • Hohmann J; Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, N.Cyprus.
  • Kirmizibekmez H; Faculty of Pharmacy, Department of Pharmacognosy, University of Szeged, Szeged, Hungary.
Nat Prod Res ; 35(23): 5294-5298, 2021 Dec.
Article en En | MEDLINE | ID: mdl-32279533
Five iridoid glycosides catalpol (1), specioside (2), ajugol (3), ajugoside (4), 8-O-acetylharpagide (5), two phenylethanoid glycosides, verbascoside (6) and glucopyranosyl-(1→Gi-6)-martynoside (7), four flavonoids, luteolin (8), luteolin 7-O-ß-glucopyranoside (9), luteolin 7-O-rutinoside (10), apigenin 7-O-rutinoside (11), quercetin 3-O-rutinoside (12) and ß-sitosterol (13) were isolated from the aerial parts of Verbascum bugulifolium Lam. for the first time. Their structures were elucidated by NMR and MS experiments. The extracts, and the isolates were evaluated for their in vitro antioxidant (DPPH•, ABTS• and CUPRAC), anti-inflammatory (LOX inhibition) and antimicrobial activities. Compounds 6 and 8 showed the highest antioxidant activity in all tests, where luteolin (8) showed the relatively best anti-inflammatory activity compared to other samples with 54.1 ± 5.0% inhibition at 1 µg/mL. All the tested compounds showed weak antimicrobial activity against tested microorganisms. This is the first phytochemical and bioactivity study on V. bugulifolium.[Figure: see text].
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Verbascum Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Verbascum Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido