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In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds.
Mahomoodally, Mohamad Fawzi; Bibi Sadeer, Nabeelah; Zengin, Gokhan; Cziáky, Zoltán; Jeko, József; Diuzheva, Alina; Sinan, Kouadio Ibrahime; Palaniveloo, Kishneth; Kim, Doo Hwan; Rengasamy, Kannan Rr.
Afiliación
  • Mahomoodally MF; Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.
  • Bibi Sadeer N; Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit 80837, Mauritius.
  • Zengin G; Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit 80837, Mauritius.
  • Cziáky Z; Department of Biology, Science Faculty, Selcuk University, Konya 42250, Turkey.
  • Jeko J; Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, 4400 Nyíregyháza, Hungary.
  • Diuzheva A; Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, 4400 Nyíregyháza, Hungary.
  • Sinan KI; Faculty of Forestry and Wood Sciences, Czech University of Life Sciences, 16500 Prague, Czech Republic.
  • Palaniveloo K; Department of Biology, Science Faculty, Selcuk University, Konya 42250, Turkey.
  • Kim DH; Institute of Ocean and Earth Sciences, Institute for Advanced Studies Building, University of Malaya, Wilayah Persekutuan Kuala Lumpur 50603, Malaysia.
  • Rengasamy KR; Department of Bioresources and Food Science, Konkuk University, Seoul 05029, Korea.
Mar Drugs ; 18(4)2020 Apr 08.
Article en En | MEDLINE | ID: mdl-32276531
Seaweeds have been exploited as both food products and therapeutics to manage human ailments for centuries. This study investigated the metabolite profile of five seaweeds (Halimeda spp., Spyridia hypnoides (Bory de Saint-Vincent) Papenfuss, Valoniopsis pachynema (G. Martens) Børgesen, Gracilaria fergusonii J. Agardh and Amphiroa anceps (Lamarck) Decaisne using ultra-high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UHPLC-ESI-MS/MS). Furthermore, these seaweeds were assessed for antioxidant and inhibitory effects against α-amylase, α-glucosidase, acetyl-cholinesterase (AChE), butyryl-cholinesterase (BChE) and tyrosinase. Valoniopsis pachynema and A. anceps yielded the highest flavonoid (4.30 ± 0.29 mg RE/g) and phenolic content (7.83 ± 0.08 mg RE/g), respectively. Additionally, A. anceps exhibited significant antioxidant properties with all assays and significantly depressed BChE (IC50 = 6.68 ± 0.83 mg/mL) and α-amylase activities (IC50 = 5.34 ± 0.14 mg/mL). Interestingly, the five seaweeds revealed potent inhibitory effects against tyrosinase activity. In conclusion, A. anceps might be considered as a key source of phytoantioxidants and a potential candidate to develop nutritional supplements. Besides, the five tested seaweeds warrant further study and may be exploited as promising natural sources for managing hyperpigmentation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Inhibidores Enzimáticos / Fitoquímicos / Antioxidantes Límite: Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Algas Marinas / Inhibidores Enzimáticos / Fitoquímicos / Antioxidantes Límite: Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza