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Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial.
Gaur, Aditya H; McCarthy, James S; Panetta, John C; Dallas, Ronald H; Woodford, John; Tang, Li; Smith, Amber M; Stewart, Tracy B; Branum, Kristen C; Freeman, Burgess B; Patel, Nehali D; John, Elizabeth; Chalon, Stephan; Ost, Shelley; Heine, Ryan N; Richardson, Julie L; Christensen, Robbin; Flynn, Patricia M; Van Gessel, Yvonne; Mitasev, Branko; Möhrle, Jörg J; Gusovsky, Fabian; Bebrevska, Lidiya; Guy, R Kiplin.
Afiliación
  • Gaur AH; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: aditya.gaur@stjude.org.
  • McCarthy JS; Department of Clinical Tropical Medicine, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
  • Panetta JC; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Dallas RH; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Woodford J; Department of Clinical Tropical Medicine, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
  • Tang L; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Smith AM; University of Tennessee Health Science Center, University of Tennessee, Memphis, TN, USA.
  • Stewart TB; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Branum KC; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Freeman BB; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Patel ND; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
  • John E; Ejohn Consulting, Richland, WA, USA.
  • Chalon S; Medicines for Malaria Venture, Geneva, Switzerland.
  • Ost S; University of Tennessee Health Science Center, University of Tennessee, Memphis, TN, USA.
  • Heine RN; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Richardson JL; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Christensen R; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Flynn PM; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Van Gessel Y; Eisai, Cambridge, MA, USA.
  • Mitasev B; Eisai, Cambridge, MA, USA.
  • Möhrle JJ; Medicines for Malaria Venture, Geneva, Switzerland.
  • Gusovsky F; Eisai, Cambridge, MA, USA.
  • Bebrevska L; Medicines for Malaria Venture, Geneva, Switzerland.
  • Guy RK; University of Kentucky College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Lancet Infect Dis ; 20(8): 964-975, 2020 08.
Article en En | MEDLINE | ID: mdl-32275867
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Malaria Falciparum / Inhibidores de la Bomba de Protones / Compuestos Heterocíclicos de 4 o más Anillos / Isoquinolinas / Antimaláricos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Malaria Falciparum / Inhibidores de la Bomba de Protones / Compuestos Heterocíclicos de 4 o más Anillos / Isoquinolinas / Antimaláricos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos