Active Ingredients and Anti-Arthritic Mechanisms of Ba-Wei-Long-Zuan Granule Revealed by <sup>1</sup> H-NMR-Based Metabolomics Combined with Network Pharmacology Analysis.

Fan, Gang; Li, Qi; Li, Hai-Jiao; Zhang, Yun-Sen; Xu, Xin-Mei; Fang, Gang; Ge, Yi-Man; Du, Lei-Lei

Active Ingredients and Anti-Arthritic Mechanisms of Ba-Wei-Long-Zuan Granule Revealed by ¹ H-NMR-Based Metabolomics Combined with Network Pharmacology Analysis.

Fan, Gang; Li, Qi; Li, Hai-Jiao; Zhang, Yun-Sen; Xu, Xin-Mei; Fang, Gang; Ge, Yi-Man; Du, Lei-Lei.

Afiliación

Fan G; School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Li Q; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Li HJ; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Zhang YS; School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Xu XM; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Fang G; Key Laboratory of Basic Research and Applied Research of Zhuang Medicine, Guangxi University of Chinese Medicine, Guangxi, 530001, P. R. China.
Ge YM; Department of Inspection, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, P. R. China.
Du LL; School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.

Chem Biodivers ; 17(6): e2000122, 2020 Jun.

Article en En | MEDLINE | ID: mdl-32274851

Asunto(s)

Antirreumáticos/química; Medicamentos Herbarios Chinos/química; Metabolómica; Animales; Antirreumáticos/metabolismo; Antirreumáticos/farmacología; Artritis Experimental/inducido químicamente; Artritis Experimental/tratamiento farmacológico; Sitios de Unión; Biomarcadores/sangre; Biomarcadores/metabolismo; Citocromo P-450 CYP1A2/química; Citocromo P-450 CYP1A2/metabolismo; Análisis Discriminante; Medicamentos Herbarios Chinos/metabolismo; Medicamentos Herbarios Chinos/uso terapéutico; Hesperidina/química; Hesperidina/metabolismo; Hesperidina/uso terapéutico; Isoquinolinas/química; Isoquinolinas/metabolismo; Isoquinolinas/uso terapéutico; Espectroscopía de Resonancia Magnética; Masculino; Medicina Tradicional China; Simulación del Acoplamiento Molecular; Análisis de Componente Principal; Estructura Terciaria de Proteína; Ratas; Ratas Wistar

Palabras clave

Ba-Wei-Long-Zuan granule; collagen-induced arthritis; metabolomics; network pharmacology; rheumatoid arthritis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Antirreumáticos / Metabolómica Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Suiza

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