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Clinical utility and value contribution of an MRI-positive line marker for image-guided brachytherapy in gynecologic malignancies.
Ning, Matthew S; Vedam, Sastry; Ma, Jingfei; Stafford, R Jason; Bruno, Teresa L; Cunningham, Mandy; Starks, Christine; Lawyer, Ann; Venkatesan, Aradhana M; Wang, Li; Wang, Jihong; Olivieri, Nicholas D; Guzman, Alexis B; Incalcaterra, James R; Thaker, Nikhil G; Joyner, Melissa M; Lin, Lilie L; Jhingran, Anuja; Eifel, Patricia J; Klopp, Ann H.
Afiliación
  • Ning MS; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Vedam S; Departments of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Ma J; Departments of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Stafford RJ; Departments of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Bruno TL; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Cunningham M; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Starks C; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Lawyer A; Departments of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Venkatesan AM; Departments of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Wang L; Departments of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Wang J; Departments of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Olivieri ND; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Guzman AB; Departments of Finance, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Incalcaterra JR; Departments of Finance, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Thaker NG; Department of Radiation Oncology, Arizona Oncology, The US Oncology Network, Tucson, AZ.
  • Joyner MM; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Lin LL; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Jhingran A; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Eifel PJ; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Klopp AH; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: aklopp@mdanderson.org.
Brachytherapy ; 19(3): 305-315, 2020.
Article en En | MEDLINE | ID: mdl-32265119
PURPOSE: The purpose of this study was to investigate the utility of a novel MRI-positive line marker, composed of C4:S (cobalt chloride-based contrast agent) encapsulated in high-density polyethylene tubing, in permitting dosimetry and treatment planning directly on MRI. METHODS AND MATERIALS: We evaluated the clinical feasibility of the C4:S line markers in nine sequential brachytherapy procedures for gynecologic malignancies, including six tandem-and-ovoid and three interstitial cases. We then quantified the internal resource utilization of an intraoperative MRI-guided procedural episode via time-driven activity-based costing, identifying opportunities for cost-containment with use of the C4:S line markers. RESULTS: The C4:S line markers demonstrated the strongest positive signal visibility on 3D constructive interference in steady state (CISS)/FIESTA-C followed by T1-weighted sequences, permitting accurate delineation of the applicator lumen and thus the source path. These images may be fused along with traditional T2-weighted sequences for optimal tumor and anatomy contouring, followed by treatment planning directly on MRI. By eliminating postoperative CT for fusion and applicator registration from the procedural episode, use of the C4:S line markers could decrease workflow time and lower total delivery costs per procedure. CONCLUSIONS: This analysis supports the clinical utility and value contribution of the C4:S line markers, which permit accurate MRI-based dosimetry and treatment planning, thereby eliminating the need for postoperative CT for fusion and applicator registration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Planificación de la Radioterapia Asistida por Computador / Braquiterapia / Imagen por Resonancia Magnética / Neoplasias de los Genitales Femeninos Límite: Female / Humans Idioma: En Revista: Brachytherapy Asunto de la revista: RADIOTERAPIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Planificación de la Radioterapia Asistida por Computador / Braquiterapia / Imagen por Resonancia Magnética / Neoplasias de los Genitales Femeninos Límite: Female / Humans Idioma: En Revista: Brachytherapy Asunto de la revista: RADIOTERAPIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos