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Occult hepatitis B infections and anti-HBc prevalence at a resource-limited blood bank in Mexico.
Hernández-Romano, Pablo; Hernández-Romano, Jesús; Torres-Hernández, Rosa M; González-Jiménez, Beatriz; López-Balderas, Nayali.
Afiliación
  • Hernández-Romano P; Centro Estatal de la Transfusión Sanguínea del Estado de Veracruz, Veracruz, Mexico.
  • Hernández-Romano J; Facultad de Bioanálisis, Región Veracruz, Universidad Veracruzana, Veracruz, Mexico.
  • Torres-Hernández RM; Universidad Politécnica del Estado de Morelos, Departamento de Biotecnología, Jiutepec, Mexico.
  • González-Jiménez B; UV-CA477 "Investigación Clínica" Facultad de Medicina, Región Veracruz, Universidad Veracruzana, Veracruz, Mexico.
  • López-Balderas N; UV-CA477 "Investigación Clínica" Facultad de Medicina, Región Veracruz, Universidad Veracruzana, Veracruz, Mexico.
Transfus Med ; 30(5): 396-400, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32250006
OBJECTIVES: To identify blood donors with occult hepatitis B infections (OBIs), determine the prevalence of antibody to hepatitis B core antigen (anti-HBc) positivity and estimate the impact of anti-HBc screening on donor deferral at CETS-Veracruz (Mexico). BACKGROUND: Hepatitis B virus infection is a major concern in transfusion medicine. Mexican regulations only mandate screening for hepatitis B surface antigen (HBsAg), and there are no requirements regarding testing for anti-HBc or use of a nucleic acid test (NAT). There is, therefore, limited information about the prevalence of anti-HBc positivity and occult hepatitis B among blood donors in Mexico. METHODS: This retrospective study examined individuals who donated blood to CETS-Veracruz from June 2014 to June 2017. All donors were serologically examined according to Mexican health regulations, and the prevalence of anti-HBc positivity was determined. A NAT was used to identify individuals with OBIs. RESULTS: We analysed the data of 28 016 blood donors. Over 4 years, the average prevalence of anti-HBc positivity was 1.05%. The risk factors for anti-HBc positivity were low education and age over 50 years. There were nine donors with OBIs. CONCLUSION: The presence of donors with OBIs in CETS-Veracruz and other Mexican blood banks highlights the need to mandate the implementation of anti-HBc screening in Mexico.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bancos de Sangre / Donantes de Sangre / Hepatitis B Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Mexico Idioma: En Revista: Transfus Med Asunto de la revista: HEMATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bancos de Sangre / Donantes de Sangre / Hepatitis B Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Mexico Idioma: En Revista: Transfus Med Asunto de la revista: HEMATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido