Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy.

Kennedy, Barry E; Sadek, Maryanne; Gujar, Shashi A

Kennedy, Barry E; Sadek, Maryanne; Gujar, Shashi A.

Afiliación

Kennedy BE; Department of Pathology, Dalhousie University, Halifax, NS B3H 1X5, Canada.
Sadek M; Department of Pathology, Dalhousie University, Halifax, NS B3H 1X5, Canada.
Gujar SA; Department of Pathology, Dalhousie University, Halifax, NS B3H 1X5, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada; Department of Biology, Dalhousie University, Halifax, NS B3H 1X5, Canada; Beatrice Hunter Cancer Research Institute, Halifax, NS B3H 1X5, Canada. Electronic address: shashi.gujar@dal.ca.

Mol Ther ; 28(6): 1417-1421, 2020 06 03.

Article en En | MEDLINE | ID: mdl-32243836

RESUMEN

Oncolytic viruses (OVs) represent a promising new class of cancer therapeutics and cause antitumor effects by two major mechanisms: (1) directly killing cancer cells in a process known as oncolysis, or (2) initiating a powerful antitumor immune response. Interestingly, energy metabolism, within either cancer cells or immune cells, plays a pivotal role in defining the outcome of OV-mediated antitumor effects. Following therapeutic administration, OVs must hijack host cell metabolic pathways to acquire building blocks such as nucleotides, lipids, and amino acids for the process of replication that is necessary for oncolysis. Additionally, OV-stimulated antitumor immune responses are highly dependent on the metabolic state within the tumor microenvironment. Thus, metabolic reprogramming strategies bear the potential to enhance the efficacy of both OV-mediated oncolysis and antitumor immune responses.

Asunto(s)

Reprogramación Celular/genética; Metabolismo Energético/genética; Terapia Genética; Vectores Genéticos/genética; Viroterapia Oncolítica; Virus Oncolíticos/genética; Animales; Terapia Genética/efectos adversos; Terapia Genética/métodos; Vectores Genéticos/administración & dosificación; Humanos; Inmunomodulación; Redes y Vías Metabólicas/genética; Neoplasias/etiología; Neoplasias/metabolismo; Neoplasias/terapia; Viroterapia Oncolítica/efectos adversos; Viroterapia Oncolítica/métodos; Fosforilación Oxidativa; Resultado del Tratamiento

Palabras clave

TCA cycle; cancer metabolism; glycolysis; immunometabolism; metabolic reprogramming; oncolytic virus; oxidative phosphorylation; pyruvate metabolism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Metabolismo Energético / Virus Oncolíticos / Viroterapia Oncolítica / Reprogramación Celular / Vectores Genéticos Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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