Your browser doesn't support javascript.
loading
Effect of chlorogenic and gallic acids combined with azoles on antifungal susceptibility and virulence of multidrug-resistant Candida spp. and Malassezia furfur isolates.
Rhimi, Wafa; Aneke, Chioma Inyang; Annoscia, Giada; Otranto, Domenico; Boekhout, Teun; Cafarchia, Claudia.
Afiliación
  • Rhimi W; Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Aldo Moro, Bari, Italy.
  • Aneke CI; Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Aldo Moro, Bari, Italy.
  • Annoscia G; Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria.
  • Otranto D; Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Aldo Moro, Bari, Italy.
  • Boekhout T; Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Aldo Moro, Bari, Italy.
  • Cafarchia C; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Med Mycol ; 58(8): 1091-1101, 2020 Nov 10.
Article en En | MEDLINE | ID: mdl-32236482
Chlorogenic acid (CHA) and gallic acid (GA) are safe natural phenolic compounds that are used as enhancers of some drugs in influencing antioxidant, anticancer, and antibacterial activities. Among fungi, Candida spp. and Malassezia spp. are characterized by an increasing prevalence of multidrug resistance phenomena and by a high morbidity and mortality of their infections. No data are available about the efficacy of CHA and GA combined with azoles on the antifungal susceptibility and on the virulence of both fungi. Therefore, their antifungal and antivirulence effects have been tested in combination with fluconazole (FLZ) or ketoconazole (KTZ) on 23 Candida spp. and 8 M. furfur isolates. Broth microdilution chequerboard, time-kill studies, and extracellular enzymes (phospholipase and hemolytic) activities were evaluated, displaying a synergistic antifungal action between CHA or GA and FLZ or KTZ on C. albicans, C. bovina, and C. parapsilosis, and antagonistic antifungal effects on M. furfur and Pichia kudriavzevii (Candida krusei) isolates. The time-kill studies confirmed the chequerboard findings, showing fungicidal inhibitory effect only when the GA was combined with azoles on Candida strains. However, the combination of phenolics with azoles had no effect on the virulence of the tested isolates. Our study indicates that the combination between natural products and conventional drugs could be an efficient strategy for combating azole resistance and for controlling fungistatic effects of azole drugs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azoles / Candida / Ácido Clorogénico / Farmacorresistencia Fúngica Múltiple / Ácido Gálico / Malassezia / Antifúngicos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azoles / Candida / Ácido Clorogénico / Farmacorresistencia Fúngica Múltiple / Ácido Gálico / Malassezia / Antifúngicos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido