Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding.

Zhang, Danyang; Zhang, Yan; Ma, Jun; Zhu, Chunmei; Niu, Tongxin; Chen, Wenbo; Pang, Xiaoyun; Zhai, Yujia; Sun, Fei

Zhang, Danyang; Zhang, Yan; Ma, Jun; Zhu, Chunmei; Niu, Tongxin; Chen, Wenbo; Pang, Xiaoyun; Zhai, Yujia; Sun, Fei.

Afiliación

Zhang D; National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhang Y; University of Chinese Academy of Sciences, Beijing, China.
Ma J; National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhu C; National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Niu T; University of Chinese Academy of Sciences, Beijing, China.
Chen W; National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Pang X; University of Chinese Academy of Sciences, Beijing, China.
Zhai Y; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Sun F; National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Elife ; 92020 03 31.

Article en En | MEDLINE | ID: mdl-32228866

Asunto(s)

Microscopía por Crioelectrón; GTP Fosfohidrolasas/metabolismo; GTP Fosfohidrolasas/ultraestructura; Fusión de Membrana; Nucleótidos/metabolismo; Animales; Dinaminas/metabolismo; GTP Fosfohidrolasas/genética; Humanos; Liposomas; Ratones; Membranas Mitocondriales/metabolismo; Proteínas Mitocondriales/metabolismo; Proteínas Mitocondriales/ultraestructura; Unión Proteica; Isoformas de Proteínas/genética

Palabras clave

OPA1; conformational change; cryo-electron microscopy; human; membrane tubulation; mitochondrial fusion; molecular biophysics; structural biology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microscopía por Crioelectrón / GTP Fosfohidrolasas / Fusión de Membrana / Nucleótidos Límite: Animals / Humans Idioma: En Revista: Elife Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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