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Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers.
Schubert, Nil A; Lowery, Caitlin D; Bergthold, Guillaume; Koster, Jan; Eleveld, Thomas F; Rodríguez, Ana; Jones, David T W; Vassal, Gilles; Stancato, Louis F; Pfister, Stefan M; Caron, Hubert N; Molenaar, Jan J.
Afiliación
  • Schubert NA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Lowery CD; Eli Lilly and Company, Indianapolis, IN, USA.
  • Bergthold G; Hoffman-La Roche, Basel, Switzerland.
  • Koster J; Department of Oncogenomics, Amsterdam University Medical Centre, Amsterdam, the Netherlands.
  • Eleveld TF; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Rodríguez A; Hoffman-La Roche, Basel, Switzerland.
  • Jones DTW; Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Vassal G; Department of Clinical Research, Gustave Roussy, Villejuif, France.
  • Stancato LF; Eli Lilly and Company, Indianapolis, IN, USA.
  • Pfister SM; Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg University Hospital, Heidelberg, Germany.
  • Caron HN; Hoffman-La Roche, Basel, Switzerland.
  • Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address: j.j.molenaar@prinsesmaximacentrum.nl.
Eur J Cancer ; 130: 168-181, 2020 05.
Article en En | MEDLINE | ID: mdl-32224415
BACKGROUND: Children with cancer are in urgent need of new therapies, as approximately 25% of patients experience a relapse and 20% succumb to their disease. Moreover, the majority of survivors suffer from clinically relevant health problems. Repurposing of targeted agents developed for adult indications could provide novel therapeutic options for paediatric cancer patients. To prioritise targeted drugs for paediatric clinical development, we applied a systematic review methodology to develop a Target Actionability Review (TAR) strategy. These TARs assess the strength and completeness of published preclinical proof-of-concept (PoC) data by structured critical appraisal of and summarising the available scientific literature for a specific target (pathway) and the associated drugs in paediatric tumours. METHODS: A sensitive literature search in PubMed was performed and relevant papers were identified. For each paper, the individual experimental findings were extracted, marked for paediatric tumour type and categorised into nine separate PoC data modules. Each experimental finding was scored for experimental outcome and quality independently by two reviewers; discrepancies were assessed by a third reviewer and resolved by adjudication. Scores corresponding to one PoC module were merged for each tumour type and visualised in a heat map matrix in the publicly available R2 data portal [r2.amc.nl]. RESULTS AND CONCLUSIONS: To test our TAR methodology, we conducted a pilot study on MDM2 and TP53. The heat map generated from analysis of 161 publications provides a rationale to support drug development in specific paediatric solid and brain tumour types. Furthermore, our review highlights tumour types where preclinical data are incomplete or lacking and for which additional preclinical testing is advisable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prueba de Estudio Conceptual / Neoplasias Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Eur J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prueba de Estudio Conceptual / Neoplasias Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Eur J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido