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Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography.
Verticchio Vercellin, Alice C; Harris, Alon; Tanga, Lucia; Siesky, Brent; Quaranta, Luciano; Rowe, Lucas W; Torabi, Rana; Agnifili, Luca; Riva, Ivano; Oddone, Francesco.
Afiliación
  • Verticchio Vercellin AC; Department of Ophthalmology, University of Pavia, Pavia, Italy.
  • Harris A; IRCCS - Fondazione Bietti, Rome, Italy.
  • Tanga L; Department of Ophthalmology, Ophthalmic Vascular Diagnostic and Research Program at Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg 22-86, New York, NY, 10029, USA.
  • Siesky B; Department of Ophthalmology, Ophthalmic Vascular Diagnostic and Research Program at Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg 22-86, New York, NY, 10029, USA. palonharris@gmail.com.
  • Quaranta L; IRCCS - Fondazione Bietti, Rome, Italy.
  • Rowe LW; Department of Ophthalmology, Ophthalmic Vascular Diagnostic and Research Program at Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg 22-86, New York, NY, 10029, USA.
  • Torabi R; Department of Ophthalmology, University of Pavia, Pavia, Italy.
  • Agnifili L; Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Riva I; Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Oddone F; Ophthalmology Clinic, Department of Medicine and Aging Science, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Graefes Arch Clin Exp Ophthalmol ; 258(6): 1237-1251, 2020 Jun.
Article en En | MEDLINE | ID: mdl-32221692
BACKGROUND/AIMS: To evaluate diurnal variations in optic nerve head (ONH) vessel density assessed by optical coherence tomography angiography (OCT-A) in healthy subjects, ocular hypertension (OHT), and open-angle glaucoma (OAG) patients. METHODS: Forty subjects (OAG, 21; OHT, 6; healthy, 13) were assessed for vessel density percentage (VD%) and flow index in the ONH (NH VD%, NH index), and in the radial peripapillary capillary layer (RPC VD%, RPC index) at 9:00, 11:00, 14:00, 16:00, and 18:00 on a single day. Repeated measures ANOVAs were used to test for changes in the parameters measured at multiple time points. RESULTS: All OCT-A parameters analyzed at the different time points were statistically lower in the OAG patients compared to both the OHT and healthy groups (p < 0.05). In the OAG group, the NH index, RPC index, NH VD%, and RPC VD% were statistically lower at 18:00 compared to 14:00, and the RPC VD% was statistically lower at 9:00 than 14:00. In the OHT group, the RPC index was statistically lower at 9:00 than 11:00. In the healthy group, the NH VD% and RPC VD% were statistically lower at 16:00 than 18:00, and the RPC index was statistically lower at 9:00 than 11:00. No other statistically significant difference was found in none of the three groups comparing any other time point (p > 0.05). CONCLUSION: In healthy subjects, OHT and OAG patients, the variations in the OCT-A derived parameters were relatively small. These results suggest that in the clinical practice the OCT-A assessment can be performed independently of the time of the day, contrasting IOP evaluation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disco Óptico / Vasos Retinianos / Glaucoma de Ángulo Abierto / Ritmo Circadiano Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disco Óptico / Vasos Retinianos / Glaucoma de Ángulo Abierto / Ritmo Circadiano Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania