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Knockdown of LINC00467 contributed to Axitinib sensitivity in hepatocellular carcinoma through miR-509-3p/PDGFRA axis.
Li, Wei; He, Yufeng; Chen, Wei; Man, Wenling; Fu, Qiang; Tan, Hongtong; Guo, Huanqing; Zhou, Jingnan; Yang, Po.
Afiliación
  • Li W; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
  • He Y; Department of Neoplastic Hematologic Disorder, Hegang Mine Crane Hospital, Hegang, 154100, Heilongjiang, China.
  • Chen W; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
  • Man W; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
  • Fu Q; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
  • Tan H; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
  • Guo H; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
  • Zhou J; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
  • Yang P; Department of Interventional and Vascular, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China. 13704810561@163.com.
Gene Ther ; 28(10-11): 634-645, 2021 11.
Article en En | MEDLINE | ID: mdl-32221502
Hepatocellular carcinoma (HCC) is a common histological class of primary liver cancer with dismal prognosis. Long noncoding RNAs (lncRNAs) are increasingly documented as participators in cancers. Present study aimed to explore the role of long intergenic nonprotein-coding RNA 467 (LINC00467) in HCC. LINC00467 was upregulated in HCC samples in TCGA database, and was confirmed to be elevated in HCC cell lines. Functionally, LINC00467 depletion impeded proliferation and invasion, induced apoptosis, and promoted cellular sensitivity to Axitinib in HCC. Mechanistically, LINC00467 performed as a sponge of microRNA (miR)-509-3p and upregulated the expression of platelet-derived growth factor receptor alpha (PDGFRA) in HCC cells. In conclusion, our study illustrated that LINC00467 promoted proliferation and invasion, impedes apoptosis, and contributed to Axitinib resistance of hepatocellular carcinoma through miR-509-3p/PDGFRA, indicating LINC00467 as a promising biological target for HCC treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / MicroARNs / ARN Largo no Codificante / Axitinib / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Gene Ther Asunto de la revista: GENETICA MEDICA / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / MicroARNs / ARN Largo no Codificante / Axitinib / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Gene Ther Asunto de la revista: GENETICA MEDICA / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido