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The development of a cryptoglandular Anal Fistula Core Outcome Set (AFCOS): an international Delphi study protocol.
Machielsen, A J H M; Iqbal, N; Kimman, M L; Sahnan, K; Adegbola, S O; Kleijnen, J; Vaizey, C J; Grossi, U; Tozer, P J; Breukink, S O.
Afiliación
  • Machielsen AJHM; Department of Surgery and Colorectal Surgery, Maastricht University Medical Centreþ, Maastricht, The Netherlands.
  • Iqbal N; Faculty of Health, Medicine & Life Sciences, Maastricht University, Maastricht, The Netherlands.
  • Kimman ML; Robin Phillips Fistula Research Unit, St Mark's Hospital, London, The United Kingdom.
  • Sahnan K; Department of Surgery and Cancer, Imperial College London, London, The United Kingdom.
  • Adegbola SO; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centreþ, Maastricht, The Netherlands.
  • Kleijnen J; Robin Phillips Fistula Research Unit, St Mark's Hospital, London, The United Kingdom.
  • Vaizey CJ; Department of Surgery and Cancer, Imperial College London, London, The United Kingdom.
  • Grossi U; Robin Phillips Fistula Research Unit, St Mark's Hospital, London, The United Kingdom.
  • Tozer PJ; Department of Surgery and Cancer, Imperial College London, London, The United Kingdom.
  • Breukink SO; Department of Family Practice; Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
United European Gastroenterol J ; 8(2): 220-226, 2020 03.
Article en En | MEDLINE | ID: mdl-32213065
PURPOSE: Cryptoglandular anal fistula is a disorder with an incidence of around 1 per 5,000 people per year in European countries. Many studies have been conducted to evaluate the effectiveness of interventions for anal fistula. However, there is considerable heterogeneity in the outcomes assessed and reported in these studies. This limits research quality and complicates evidence synthesis. A solution for heterogeneity in outcome reporting is the development of a Core Outcome Set (COS). This paper describes the protocol for the development of a European COS for Anal Fistula (AFCOS). METHODS: The first step will be a systematic review of the literature to identify potential outcomes that may be included in the COS. Patient interviews will be conducted in The United Kingdom and The Netherlands to ensure that both clinician-important and patient-important outcomes are captured. The outcomes will be categorized using the COMET taxonomy and taken forward to a Delphi consensus exercise. In up to three web-based Delphi surveys the outcomes will be prioritized by patients, clinicians (surgeons, gastroenterologists, and radiologists), and (clinical) researchers. The responses will be summarized and reported anonymously in subsequent round(s) facilitating convergence to a consensus opinion. The final COS will be decided during a face-to-face consensus meeting with patients, clinicians, and (clinical) researchers. DISCUSSION: This study protocol describes the development of a European COS for anal fistula to improve research quality, evidence synthesis, and patient care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Qualitative_research / Systematic_reviews Idioma: En Revista: United European Gastroenterol J Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Qualitative_research / Systematic_reviews Idioma: En Revista: United European Gastroenterol J Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido