Immunomodulating Properties of Carrageenan from Tichocarpus crinitus.
Inflammation
; 43(4): 1387-1396, 2020 Aug.
Article
en En
| MEDLINE
| ID: mdl-32212036
Several in vivo immunotropic effects of κ/ß-carrageenan isolated from the red algae Tichocarpus crinitus were studied, by orally administering it at 100 mg/kg/day to mice for 7 days. Serum levels of IFN-γ, IL-12, IL-1ß, and IL-4 were measured. Carrageenan's ability to influence development of LPS-induced inflammation was also assessed. Oral administration of κ/ß-carrageenan increased serum levels of all the studied cytokines at least twice in comparison to the intact mice, while intraperitoneal LPS injection at 1 mg/kg increased concentration of only the pro-inflammatory cytokines: IFN-γ, IL-12, and IL-1ß. Furthermore, κ/ß-carrageenan demonstrated a higher efficacy at inducing IFN-γ production than LPS. Previous 7-day-long oral carrageenan administration impaired development of LPS-induced inflammation: level of IL-1ß dropped below that found in intact mice, while IFN-γ and IL-12 concentrations were at least 40% lower than in mice with LPS-induced inflammation. Murine peritoneal macrophages were also affected by the oral administration of the κ/ß-carrageenan: their motility was increased, and morphology altered. In sum, we have demonstrated that κ/ß-carrageenan, when administered orally, is not only not immunologically inert, but at the dose of 100 mg/kg possesses pharmacologically exploitable effects.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carragenina
/
Rhodophyta
/
Factores Inmunológicos
/
Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Inflammation
Año:
2020
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Estados Unidos