Determination of 17-hydroxyprogesterone in plasma by gas chromatography-mass spectrometry with high-resolution selected-ion monitoring.
J Chromatogr
; 432: 21-8, 1988 Nov 18.
Article
en En
| MEDLINE
| ID: mdl-3220889
A method for determining 17-hydroxyprogesterone in plasma by isotope dilution-mass spectrometry is described. For the internal standard 17-hydroxy [2H4]progesterone is used. Extraction of plasma is followed by conversion into the 3,20-dienol,17-tristrimethylsilyl ether derivative and analysis by capillary gas chromatography-mass spectrometry with selected-ion monitoring, at a resolution of 6000. The lower limit of quantitation was 1 pg, judged from a criterion of a signal-to-noise ratio of 10. The precision and accuracy of the method were satisfactory.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hidroxiprogesteronas
Límite:
Humans
Idioma:
En
Revista:
J Chromatogr
Año:
1988
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Países Bajos