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2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment.
Lee, Seungbeom; Kim, Dae Gyu; Kim, Kyeojin; Kim, Taewoo; Lim, Semi; Kong, Hyejin; Kim, Sunghoon; Suh, Young-Ger.
Afiliación
  • Lee S; College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea.
  • Kim DG; College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
  • Kim K; Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Kim T; College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
  • Lim S; College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea.
  • Kong H; College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
  • Kim S; Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • Suh YG; College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea.
J Med Chem ; 63(8): 3908-3914, 2020 04 23.
Article en En | MEDLINE | ID: mdl-32208684
Aminoacyl-tRNA synthetase interacting multifunctional proteins (AIMPs) have recently been considered novel therapeutic targets in several cancers. In this publication we report the development of novel 2-aminophenylpyrimidines as new AIMP2-DX2 inhibitors. In particular, aminophenylpyrimidine 3 not only exhibited promising in vitro and in vivo potency but also exerted selective inhibition of H460 and A549 cells and AIMP2-DX2 rather than WI-26 cells and AIMP2. Aminophenylpyrimidine 3 offers possible therapeutic potential in the treatment of lung cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Proteínas Nucleares / Aminoacil-ARNt Sintetasas / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Proteínas Nucleares / Aminoacil-ARNt Sintetasas / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos