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MRI estimated changes in visceral adipose tissue and liver fat fraction in patients with obesity during a very low-calorie-ketogenic diet compared to a standard low-calorie diet.
Cunha, G M; Correa de Mello, L Lugarino; Hasenstab, K A; Spina, L; Bussade, I; Prata Mesiano, J Marques; Coutinho, W; Guzman, G; Sajoux, I.
Afiliación
  • Cunha GM; Liver Imaging Group, Radiology, University of California San Diego, California, USA; MRI Department, Clínica de Diagnóstico por Imagem - CDPI/DASA, Rio de Janeiro, Brazil. Electronic address: gcunha@health.ucsd.edu.
  • Correa de Mello LL; Serviço de Obesidade, Transtornos Alimentares e Metabologia (SOTAM), Instituto Estadual de Endocrinologia (IEDE), Rio de Janeiro, Brazil.
  • Hasenstab KA; Liver Imaging Group, Radiology, University of California San Diego, California, USA.
  • Spina L; CliniCoop, Rio de Janeiro, Brazil.
  • Bussade I; Departamento de Pós-Graduação Em Clínica Médica, Pontifícia Universidade Católica (PUC), Rio de Janeiro, Brazil.
  • Prata Mesiano JM; MRI Department, Clínica de Diagnóstico por Imagem - CDPI/DASA, Rio de Janeiro, Brazil.
  • Coutinho W; Serviço de Obesidade, Transtornos Alimentares e Metabologia (SOTAM), Instituto Estadual de Endocrinologia (IEDE), Rio de Janeiro, Brazil.
  • Guzman G; Medical Department Pronokal, Barcelona, Spain.
  • Sajoux I; Medical Department Pronokal, Barcelona, Spain.
Clin Radiol ; 75(7): 526-532, 2020 07.
Article en En | MEDLINE | ID: mdl-32204895
AIM: To compare the changes in visceral adipose tissue (VAT), liver fat fraction, and liver stiffness using quantitative magnetic resonance imaging (MRI) during a very-low-calorie ketogenic (VLCK) diet and a standard low-calorie diet (LC). MATERIALS AND METHODS: The study involved secondary analysis of prospective collected clinical data. Patients undergoing weight loss interventions were randomised to either a LC or a VLCK diet. VAT, liver fat fraction, and stiffness were measured at baseline and after 2 months. RESULTS: Forty-six patients were included; 39 patients were evaluated at baseline and at 2 months follow-up. Mean weight loss was -9.7±3.8 kg (interquartile range [IQR]: -12.3; -7 kg) in the VLCK group and -1.67±2.2 kg (IQR: -3.3, -0.1 kg) in the LC group (p<0.0001). Mean VAT reductions were -39.3±40 cm2 (IQR: -52, -10 cm2) and -12.5±38.3 cm2 (IQR: -29, 5 cm2; p=0.0398), and mean liver proton density fat fraction (PDFF) reductions were -4.77±4.2% (IQR: -7.3, -1.7%) and -0.79±1.7%, (IQR: -1.8, -0.4%; p<0.005) in the VLCK group and in the LC group, respectively. No significant changes in liver stiffness occurred from baseline to follow-up. CONCLUSION: A VLCK diet resulted in greater weight loss than a standard low-calorie diet and in significantly greater reduction in liver PDFF. As anthropometric measurements may not correlate with liver fat changes, it may be advantageous to include quantitative MRI to the monitoring strategies of patients undergoing weight-loss programmes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Restricción Calórica / Grasa Intraabdominal / Dieta Cetogénica / Hígado / Obesidad Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Radiol Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Restricción Calórica / Grasa Intraabdominal / Dieta Cetogénica / Hígado / Obesidad Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Radiol Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido