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Biomimetic TiO2-chitosan/sodium alginate blended nanocomposite scaffolds for tissue engineering applications.
Kolathupalayam Shanmugam, Balu; Rangaraj, Suriyaprabha; Subramani, Karthik; Srinivasan, Surendhiran; Aicher, Wilhelm K; Venkatachalam, Rajendran.
Afiliación
  • Kolathupalayam Shanmugam B; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India.
  • Rangaraj S; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India.
  • Subramani K; Department of Biotechnoloy, Dr. N. G. P. Arts and Science College, Coimbatore 641048, Tamil Nadu, India.
  • Srinivasan S; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India.
  • Aicher WK; Department of Urology, University of Tübingen Hospital, Waldhörnlestr. 22, 72072 Tübingen, Germany.
  • Venkatachalam R; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India; Centre for Nano Science and Technology, Dr. N. G. P. Arts and Science College, Coimbatore 641048, Tamil Nadu, India. Electronic address: vrajendran@drngpasc.ac.in.
Mater Sci Eng C Mater Biol Appl ; 110: 110710, 2020 May.
Article en En | MEDLINE | ID: mdl-32204022
The study is aimed to synthesize potent metal oxide based biomimetic nanocomposites to overcome the risk associated with artificial bone tissue engineering. High purity TiO2 nanoparticles are synthesized via hydrothermal route. A biomimetic nanocomposite scaffolds containing chitosan-sodium alginate (4: 4) blended with three different (0.5, 1, and 1.5 wt%) concentrations of hydrothermally synthesized TiO2 nanoparticles are obtained by solvent casting technique. The physico-chemical and thermal degradation properties of as-synthesized TiO2 nanoparticles and their nanocomposite scaffolds are analyzed. In-vitro cytotoxicity and biocompatibility of the prepared TiO2 nanoparticles and nanocomposites are tested against human bladder tumor (UC6) and osteosarcoma (MG-63) cell lines. Antibacterial property is tested against Escherichia coli and Staphylococcus aureus. These studies reveal that TiO2 nanoparticles and polymeric nanocomposites contain good physico-chemical and mechanical properties for enhanced in-vitro biocompatibility suitable for biomedical applications. Biomimetically prepared chitosan-sodium alginate scaffold containing TiO2 nanoparticles (1 wt%) is found to exhibit superior biocompatibility for bone tissue engineering applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Ensayo de Materiales / Ingeniería de Tejidos / Materiales Biomiméticos / Escherichia coli / Nanocompuestos / Andamios del Tejido / Antibacterianos Límite: Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2020 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Ensayo de Materiales / Ingeniería de Tejidos / Materiales Biomiméticos / Escherichia coli / Nanocompuestos / Andamios del Tejido / Antibacterianos Límite: Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2020 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos