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Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction.
Slesarchuk, Nikita A; Khvatov, Evgeny V; Chistov, Alexey A; Proskurin, Gleb V; Nikitin, Timofei D; Lazarevich, Anastasiya I; Ulanovskaya, Angelina A; Ulashchik, Egor A; Orlov, Alexey A; Jegorov, Artjom V; Ustinov, Alexey V; Tyurin, Anton P; Shmanai, Vadim V; Ishmukhametov, Aydar A; Korshun, Vladimir A; Osolodkin, Dmitry I; Kozlovskaya, Liubov I; Aralov, Andrey V.
Afiliación
  • Slesarchuk NA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia; Department of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 117312, Russia.
  • Khvatov EV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; FSBSI «Chumakov FSC R&D IBP RAS¼, Moscow 108819, Russia.
  • Chistov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Department of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 117312, Russia.
  • Proskurin GV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia.
  • Nikitin TD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
  • Lazarevich AI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Mendeleev University of Chemical Technology, Moscow 125047, Russia.
  • Ulanovskaya AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Mendeleev University of Chemical Technology, Moscow 125047, Russia.
  • Ulashchik EA; Institute of Physico-Organic Chemistry, Minsk 220072, Belarus.
  • Orlov AA; FSBSI «Chumakov FSC R&D IBP RAS¼, Moscow 108819, Russia.
  • Jegorov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia.
  • Ustinov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Department of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 117312, Russia. Electronic address: austinov@yandex.ru.
  • Tyurin AP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Department of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 117312, Russia; Gause Institute of New Antibiotics, Moscow 119021, Russia.
  • Shmanai VV; Institute of Physico-Organic Chemistry, Minsk 220072, Belarus.
  • Ishmukhametov AA; FSBSI «Chumakov FSC R&D IBP RAS¼, Moscow 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
  • Korshun VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia; Department of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 117312, Russia; Gause Institute of New Antibiotics, Moscow 119021, Russia.
  • Osolodkin DI; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia; FSBSI «Chumakov FSC R&D IBP RAS¼, Moscow 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow 119991, Russia. Electronic address: osolodkin_
  • Kozlovskaya LI; FSBSI «Chumakov FSC R&D IBP RAS¼, Moscow 108819, Russia; Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
  • Aralov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia.
Bioorg Med Chem Lett ; 30(10): 127100, 2020 05 15.
Article en En | MEDLINE | ID: mdl-32199731
Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moiety, then converting uridine to aniline, then moving to perylenylthiophenecarboxylic acids and to perylenylcarboxylic acid. All these polyaromatic compounds, as well as antibiotic heliomycin, still showed pronounced activity against tick-borne encephalitis virus (TBEV) with limited toxicity in porcine embryo kidney (PEK) cell line. 5-(Perylen-3-yl)-2-thiophenecarboxylic acid (5a) showed the highest antiviral activity with 50% effective concentration of approx. 1.6 nM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Perileno / Garrapatas / Virus de la Encefalitis Transmitidos por Garrapatas Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Perileno / Garrapatas / Virus de la Encefalitis Transmitidos por Garrapatas Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido