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Interactions of OXTR rs53576 and emotional trauma on hippocampal volumes and perceived social support in adolescent girls.
Malhi, Gin S; Das, Pritha; Outhred, Tim; Dobson-Stone, Carol; Bell, Erica; Gessler, Danielle; Bryant, Richard; Mannie, Zola.
Afiliación
  • Malhi GS; The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shor
  • Das P; The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shor
  • Outhred T; The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shor
  • Dobson-Stone C; The University of Sydney, Brain and Mind Centre, Faculty of Medicine and Health, NSW, Australia; School of Medical Sciences, University of New South Wales, NSW, Australia.
  • Bell E; The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shor
  • Gessler D; The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shor
  • Bryant R; School of Psychology, University of New South Wales, NSW, Australia.
  • Mannie Z; The University of Sydney, Faculty of Medicine and Health, Northern Clinical School, Department of Psychiatry, Sydney, NSW, Australia; Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia; CADE Clinic, Royal North Shor
Psychoneuroendocrinology ; 115: 104635, 2020 05.
Article en En | MEDLINE | ID: mdl-32199286
Oxytocin (OXT) is a neuropeptide involved in social behaviour and is sensitive to environmental influences to alter individual vulnerability or resilience to stress resulting in both negative and positive outcomes. The effects of the OXT receptor (OXTR) single nucleotide polymorphism (SNP) rs53576 on hippocampal and amygdala structure and functions in adults are differentially associated with susceptibility to adversity and social behaviours, but this evidence is lacking in healthy adolescents. Adolescence is a developmental period characterised by neurobiological and psychosocial changes resulting in higher susceptibility to mood disorders, particularly among girls. As the brain is highly plastic at this stage, to understand psychosocial and emotional development, clarity of the interactions between rs53576 and adversity on hippocampal and amygdala volumes and social behaviours is needed. In this study, we investigated the interactions between rs53576 and emotional trauma (ET) exposure on hippocampal and amygdala volumes of adolescent girls, and associations with parenting style, perceived social support and bullying behaviour. Based on an unbiased and corrected analytical approach, we found smaller left hippocampal volumes in higher (hET) compared to minimally (mET) exposed AA homozygotes, but no differences in G allele carriers nor in the amygdala. Within the mET AA group, larger volumes were associated with peer perceived social support, but in their hET counterparts, smaller volumes were associated with familial perceived social support. This evidence supports an important role for the hippocampus in social behaviours but extends current knowledge to suggest that hippocampal social behavioural features are contextually dependent on rs53576.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoyo Social / Maltrato a los Niños / Receptores de Oxitocina / Resiliencia Psicológica / Interacción Gen-Ambiente / Trauma Psicológico / Hipocampo Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adolescent / Child / Female / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoyo Social / Maltrato a los Niños / Receptores de Oxitocina / Resiliencia Psicológica / Interacción Gen-Ambiente / Trauma Psicológico / Hipocampo Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adolescent / Child / Female / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido