Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.
Immun Ageing
; 17: 6, 2020.
Article
en En
| MEDLINE
| ID: mdl-32190092
Patients with rheumatoid arthritis (RA) develop features of accelerated ageing, including immunosenescence. These changes include decreased thymic functionality, expansion of late-differentiated effector T cells, increased telomeric attrition, and excessive production of cytokines (senescence-associated secretory phenotype). The progression of RA has been associated with the early development of age-related co-morbidities, including osteoporosis, cardiovascular complications, and cognitive impairment. Here I review data supporting the hypothesis that immune-senescence contributes to the aggravation of both articular and extra-articular manifestations. Of note, poor cognitive functions in RA were associated with senescent CD28- T cells, inflammaging, and autoantibodies against brain antigens. The pathways of immune-to-brain communication are discussed and provide the rationale for the cognitive impairment reported in RA.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Immun Ageing
Año:
2020
Tipo del documento:
Article
Pais de publicación:
Reino Unido