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Bioinspired Helical Micromotors as Dynamic Cell Microcarriers.
Yu, Yunru; Guo, Jiahui; Wang, Yuetong; Shao, Changmin; Wang, Yu; Zhao, Yuanjin.
Afiliación
  • Yu Y; Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
  • Guo J; Department of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Nanjing 210008, China.
  • Wang Y; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
  • Shao C; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
  • Wang Y; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
  • Zhao Y; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
ACS Appl Mater Interfaces ; 12(14): 16097-16103, 2020 Apr 08.
Article en En | MEDLINE | ID: mdl-32181642
Micromotors have exhibited great potential in multidisciplinary nanotechnology, environmental science, and especially biomedical engineering due to their advantages of controllable motion, long lifetime, and high biocompatibility. Marvelous efforts focusing on endowing micromotors with novel characteristics and functionalities to promote their applications in biomedical engineering have been taken in recent years. Here, inspired by the flagellar motion of Escherichia coli, we present helical micromotors as dynamic cell microcarriers using simple microfluidic spinning technology. The morphologies of micromotors can be easily tailored because of the highly controllable and feasible fabrication process including microfluidic generation and manual dicing. Benefiting from the biocompatibility of the materials, the resultant helical micromotors could be ideal cell microcarriers that are suitable for cell seeding and further cultivation; the magnetic nanoparticle encapsulation imparts the helical micromotors with kinetic characteristics in response to mobile magnetic fields. Thus, the helical micromotors could be applied as dynamic cell culture blocks and further assembled to complex geometrical structures. The constructed structures out of cell-seeded micromotors could find practical potential in biomedical applications as the stack-shaped assembly embedded in the hydrogel may be used for tissue repairing and the tube-shaped assembly due to its resemblance to vascular structures in the microchannel for organ-on-a-chip study or blood vessel regeneration. These features manifest the possibility to broaden the biomedical application scope for micromotors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Nanotecnología / Microfluídica / Nanopartículas Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Nanotecnología / Microfluídica / Nanopartículas Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos