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Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens.
Remington, Benjamin C; Westerhout, Joost; Meima, Marie Y; Blom, W Marty; Kruizinga, Astrid G; Wheeler, Matthew W; Taylor, Steve L; Houben, Geert F; Baumert, Joseph L.
Afiliación
  • Remington BC; The Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.
  • Westerhout J; The Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.
  • Meima MY; The Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.
  • Blom WM; The Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands. Electronic address: marty.blom@tno.nl.
  • Kruizinga AG; The Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.
  • Wheeler MW; Risk Evaluation Branch, National Institute for Occupational Safety and Health, Cincinnati, OH, United States.
  • Taylor SL; Food Allergy Research and Resource Program, University of Nebraska, Lincoln, USA.
  • Houben GF; The Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.
  • Baumert JL; Food Allergy Research and Resource Program, University of Nebraska, Lincoln, USA.
Food Chem Toxicol ; 139: 111259, 2020 May.
Article en En | MEDLINE | ID: mdl-32179163
Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset were published for 11 allergenic foods in 2014. Systematic data collection has continued (2011-2018) and the dataset now contains over 3400 data points. The current study provides new and updated EDp values for 14 allergenic foods and incorporates a newly developed Stacked Model Averaging statistical method for interval-censored data. ED01 and ED05 values, the doses at which 1%, and respectively 5%, of the respective allergic population would be predicted to experience any objective allergic reaction were determined. The 14 allergenic foods were cashew, celery, egg, fish, hazelnut, lupine, milk, mustard, peanut, sesame, shrimp (for crustacean shellfish), soy, walnut, and wheat. Updated ED01 estimates ranged between 0.03 mg for walnut protein and 26.2 mg for shrimp protein. ED05 estimates ranged between 0.4 mg for mustard protein and 280 mg for shrimp protein. The ED01 and ED05 values presented here are valuable in the risk assessment and subsequent risk management of allergenic foods.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alérgenos / Hipersensibilidad a los Alimentos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Food Chem Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alérgenos / Hipersensibilidad a los Alimentos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Food Chem Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido