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Barrier Protection Measures for the Management of Allergic Rhinitis: A Systematic Review and Meta-analysis.
Chen, Xianzhen; Deng, Chuntao; Mi, Jiaoping; Chen, Mo; Li, Yanfei; Liu, Zhigang; Feng, Shaoyan.
Afiliación
  • Chen X; Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  • Deng C; Department of Radiation Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  • Mi J; Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  • Chen M; Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  • Li Y; Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  • Liu Z; Department of Head and Neck Oncology, Phase 1 Clinical Trial Ward, The Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  • Feng S; Department of Otorhinolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Am J Rhinol Allergy ; 34(4): 564-572, 2020 Jul.
Article en En | MEDLINE | ID: mdl-32178523
BACKGROUND: Pharmacotherapy for allergic rhinitis (AR) still remains unsatisfying regarding its effect and safety. Barrier protection measures may be a good choice for the patients with AR. OBJECTIVE: To assess the efficacy and safety of barrier protection measures in the treatment of AR. METHODS: We selected relevant randomized controlled trials published between January 1, 1990, and February 20, 2019, by searching Embase, PubMed, Cochrane, Web of Knowledge, and ClinicalTrials.gov. The primary outcome for this analysis was rhinitis symptom scores, overall quality of life, nasal peak inspiratory flow (NPIF), and adverse events. Differences were expressed as weighted mean difference (WMD) with 95% confidence intervals (CIs) for continuous outcomes. Statistical heterogeneity across trials was assessed with the statistic (P < .1) and the I2 statistic. RESULTS: Fifteen RCTs (with data for 1154 participants) satisfied our inclusion criteria. The types of barrier protection measures comprised cellulose, pollen blocker cream, microemulsion, and nasal filter. To reduce the potential risk of bias and heterogeneity, we carried out subgroup analysis according to different types of barrier protection measures (cellulose: WMD = -2.18, 95% CI, -3.01 to -1.35, P < .00001; pollen blocker cream: WMD = -4.55, 95% CI, -6.10 to -3.00, P < .00001; microemulsion: WMD = -0.22, 95% CI, -0.42 to -0.03, P = .03). Findings from our meta-analysis show that, compared with placebo, barrier protection measures can yield improved symptomatic control for AR, with no increase in adverse events. Furthermore, barrier protection measures can improve the quality of life and NPIF. CONCLUSION: Although further studies are still needed, our findings clearly lend support to barrier protection measures as a safe and efficacious option for the treatment of AR patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rinitis Alérgica Estacional / Crema para la Piel Tipo de estudio: Clinical_trials / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Am J Rhinol Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA / OTORRINOLARINGOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rinitis Alérgica Estacional / Crema para la Piel Tipo de estudio: Clinical_trials / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Am J Rhinol Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA / OTORRINOLARINGOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos