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Effects of spongioplasty on neourethral function following hypospadias repair: an experimental study in rabbits.
Xie, Linhai; Xi, Yaqi; Zhang, Xue; Ding, Hongbiao; Li, Senkai.
Afiliación
  • Xie L; Department of Plastic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
  • Xi Y; Department of Plastic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
  • Zhang X; Department of Plastic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
  • Ding H; Department of Plastic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
  • Li S; Hypospadias Treatment Center, Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Int Braz J Urol ; 46(3): 436-443, 2020.
Article en En | MEDLINE | ID: mdl-32167710
PURPOSE: Spongioplasty (mobilization and midline approximation of the two branches of the bifid dysplastic distal corpus spongiosum) can form a covering layer for the neourethra to prevent urethrocutaneous fistula in hypospadias repair surgery. However, it remains unclear whether spongioplasty affects neourethral function. The objective of this study was to compare neourethral function after hypospadias repair with and without spongioplasty. MATERIALS AND METHODS: Fourteen congenital hypospadiac New Zealand male rabbits were randomly allocated into two groups, seven animals underwent Duplay hypospadias repair and spongioplasty (experimental group), while seven underwent Duplay surgery alone (control group). Functional differences between groups were assessed by comparing neourethral compliance and flow rate. Two months after surgery, in vivo neourethral compliance was assessed by measuring intraluminal pressure with a digital pressure meter of an isolated neourethral segment, following progressive distension with 1, 2, and 3mL of air. Penises were harvested for uroflowmetry test using a simple device. RESULTS: Postoperatively, fistula developed in one and zero rabbits in the control and experimental groups, respectively. Mean pressures tended to be higher in the experimental group than in the control group (82.14 vs. 69.57, 188.43 vs. 143.26, and 244.71 vs. 186.29mmHg for 1, 2, and 3mL of air, respectively), but the difference was not statistically significant. Mean flow rates also did not significantly differ between the experimental and control groups (2.93mL/s vs. 3.31mL/s). CONCLUSION: In this congenital rabbit model, no obvious functional differences were found between reconstructed urethras after hypospadias repair with and without spongioplasty.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipospadias Tipo de estudio: Clinical_trials Límite: Animals / Humans / Infant / Male Idioma: En Revista: Int Braz J Urol Asunto de la revista: UROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipospadias Tipo de estudio: Clinical_trials Límite: Animals / Humans / Infant / Male Idioma: En Revista: Int Braz J Urol Asunto de la revista: UROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil