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Relationship between the Surface Roughness of Biodegradable Mg-Based Bulk Metallic Glass and the Osteogenetic Ability of MG63 Osteoblast-Like Cells.
Wong, Pei-Chun; Song, Sin-Mao; Tsai, Pei-Hua; Nien, Yi-Yuan; Jang, Jason Shian-Ching; Cheng, Cheng-Kung; Chen, Chih-Hwa.
Afiliación
  • Wong PC; School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.
  • Song SM; Institute of Materials Science and Engineering, National Central University, Taoyuan 320, Taiwan.
  • Tsai PH; Institute of Materials Science and Engineering, National Central University, Taoyuan 320, Taiwan.
  • Nien YY; Institute of Materials Science and Engineering, National Central University, Taoyuan 320, Taiwan.
  • Jang JS; Institute of Materials Science and Engineering, National Central University, Taoyuan 320, Taiwan.
  • Cheng CK; Department of Mechanical Engineering, National Central University, Taoyuan 320, Taiwan.
  • Chen CH; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Materials (Basel) ; 13(5)2020 Mar 06.
Article en En | MEDLINE | ID: mdl-32155846
Mg-based bulk metallic glass materials have been investigated for their large potential for application in orthopedic implants due to their biocompatibility, low degradation rate, and osteogenetic ability. As an orthopedic implant, initial cell adhesion has been a critical issue for subsequent osteogenesis and bone formation because the first contact between cells and the implant occurs upon the implants surface. Here, we aimed to create Mg-based bulk metallic glass samples with three different surface roughness attributes in order to understand the degradation behavior of Mg-based bulk metallic glass and the adhesion ability and osteogenetic ability of the contact cells. It was found that the degradation behavior of Mg66Zn29Ca5 bulk metallic glass was not affected by surface roughness. The surface of the Mg66Zn29Ca5 bulk metallic glass samples polished via #800 grade sandpaper was found to offer a well-attached surface and to provide a good cell viability environment for Human MG63 osteoblast-like cell line. In parallel, more calcium and mineral deposition was investigated on extracellular matrix with higher surface roughness that verify the relationship between surface roughness and cell performance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Materials (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Materials (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza