Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H.

Walker, Melissa M; Kim, Soojin; Crisler, William J; Nguyen, Kimberlie; Lenz, Laurel L; Cambier, John C; Getahun, Andrew

Walker, Melissa M; Kim, Soojin; Crisler, William J; Nguyen, Kimberlie; Lenz, Laurel L; Cambier, John C; Getahun, Andrew.

Afiliación

Walker MM; Department of Immunology and Microbiology, University of Colorado SOM, Aurora, CO, United States.
Kim S; Department of Immunology and Microbiology, University of Colorado SOM, Aurora, CO, United States.
Crisler WJ; Department of Immunology and Microbiology, University of Colorado SOM, Aurora, CO, United States.
Nguyen K; Department of Immunology and Microbiology, University of Colorado SOM, Aurora, CO, United States.
Lenz LL; Department of Immunology and Microbiology, University of Colorado SOM, Aurora, CO, United States.
Cambier JC; Department of Biomedical Sciences, National Jewish Health, Denver, CO, United States.
Getahun A; Department of Immunology and Microbiology, University of Colorado SOM, Aurora, CO, United States.

Front Immunol ; 11: 238, 2020.

Article en En | MEDLINE | ID: mdl-32153571

Asunto(s)

Mordeduras y Picaduras/metabolismo; Genotipo; Macrófagos/inmunología; Alelos; Animales; Mordeduras y Picaduras/genética; Técnicas de Sustitución del Gen; Ratones; Ratones Transgénicos; Nucleótidos Cíclicos/metabolismo; Polimorfismo Genético

Palabras clave

STING; allelic variants; cGAS; cancer; cyclic dinucleotide; immunotherapy; infection

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mordeduras y Picaduras / Genotipo / Macrófagos Límite: Animals Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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