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UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings.
McFall, Aisling; Hietamies, Tuuli M; Bernard, Ashton; Aimable, Margaux; Allan, Stuart M; Bath, Philip M; Brezzo, Gaia; Carare, Roxana O; Carswell, Hilary V; Clarkson, Andrew N; Currie, Gillian; Farr, Tracy D; Fowler, Jill H; Good, Mark; Hainsworth, Atticus H; Hall, Catherine; Horsburgh, Karen; Kalaria, Rajesh; Kehoe, Patrick; Lawrence, Catherine; Macleod, Malcolm; McColl, Barry W; McNeilly, Alison; Miller, Alyson A; Miners, Scott; Mok, Vincent; O'Sullivan, Michael; Platt, Bettina; Sena, Emily S; Sharp, Matthew; Strangward, Patrick; Szymkowiak, Stefan; Touyz, Rhian M; Trueman, Rebecca C; White, Claire; McCabe, Chris; Work, Lorraine M; Quinn, Terence J.
Afiliación
  • McFall A; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • Hietamies TM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • Bernard A; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • Aimable M; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Allan SM; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
  • Bath PM; Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
  • Brezzo G; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Carare RO; Faculty of Medicine, University of Southampton, Southampton, UK.
  • Carswell HV; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, UK.
  • Clarkson AN; The Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
  • Currie G; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Farr TD; School of Life Sciences, University of Nottingham, Nottingham , UK.
  • Fowler JH; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Good M; School of Psychology, Cardiff University, Cardiff, UK.
  • Hainsworth AH; Molecular & Clinical Sciences Research Institute, St George's University of London, London, UK.
  • Hall C; School of Psychology, University of Sussex, Brighton, UK.
  • Horsburgh K; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Kalaria R; Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.
  • Kehoe P; Institute of Clinical Neurosciences, University of Bristol, Bristol, UK.
  • Lawrence C; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
  • Macleod M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • McColl BW; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • McNeilly A; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
  • Miller AA; School of Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland.
  • Miners S; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • Mok V; Institute of Clinical Neurosciences, University of Bristol, Bristol, UK.
  • O'Sullivan M; Gerald Choa Neuroscience Centre, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
  • Platt B; Faculty of Medicine, The University of Queensland, Queensland, Australia.
  • Sena ES; Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland.
  • Sharp M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Strangward P; Faculty of Medicine, University of Southampton, Southampton, UK.
  • Szymkowiak S; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
  • Touyz RM; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Trueman RC; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
  • White C; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • McCabe C; School of Life Sciences, University of Nottingham, Nottingham , UK.
  • Work LM; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
  • Quinn TJ; Institute of Neuroscience & Psychology, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
J Cereb Blood Flow Metab ; 40(7): 1402-1414, 2020 07.
Article en En | MEDLINE | ID: mdl-32151228
Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, six themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured, and therefore that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proyectos de Investigación / Demencia Vascular / Modelos Animales de Enfermedad Tipo de estudio: Guideline / Prognostic_studies / Systematic_reviews Límite: Animals País/Región como asunto: Europa Idioma: En Revista: J Cereb Blood Flow Metab Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proyectos de Investigación / Demencia Vascular / Modelos Animales de Enfermedad Tipo de estudio: Guideline / Prognostic_studies / Systematic_reviews Límite: Animals País/Región como asunto: Europa Idioma: En Revista: J Cereb Blood Flow Metab Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos