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Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa.
Klein-Júnior, Luiz C; Cretton, Sylvian; Vander Heyden, Yvan; Gasper, André L; Nejad-Ebrahimi, Samad; Christen, Philippe; Henriques, Amélia T.
Afiliación
  • Klein-Júnior LC; Laboratory of Pharmacognosy and Quality Control of Phytomedicines, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul-UFRGS, 90610-000 Porto Alegre/RS Brazil.
  • Cretton S; Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, Center for Pharmaceutical Research (CePhaR), Vrije Universiteit Brussel-VUB, B-1090 Brussels, Belgium.
  • Vander Heyden Y; School of Health Sciences, Universidade do Vale do Itajaí-UNIVALI, 88302-901, Itajaí/SC Brazil.
  • Gasper AL; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva 4, Switzerland.
  • Nejad-Ebrahimi S; Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, Center for Pharmaceutical Research (CePhaR), Vrije Universiteit Brussel-VUB, B-1090 Brussels, Belgium.
  • Christen P; Herbarium Dr. Roberto Miguel Klein, Department of Natural Sciences, Universidade Regional de Blumenau-FURB, 89030-903 Blumenau/SC Brazil.
  • Henriques AT; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin 1983963113, Tehran Iran.
J Nat Prod ; 83(4): 852-863, 2020 04 24.
Article en En | MEDLINE | ID: mdl-32150413
Phytochemical investigation of the alkaloid extract of the aerial parts of Psychotria nemorosa led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3), and B (12), nemorosinosides A-F (4-9), as well as two ß-carboline derivatives, 10-hydroxyisodolichantoside (10) and 10-hydroxydolichantoside (11), an isoxazole alkaloid, nemorosinoside G (13), serotonin (14), bufotenine (15), and (S)-gentianol (16). Compounds 3-13 have not yet been described. These compounds were isolated by semipreparative HPLC, and their structures were determined by means of HRMS, NMR, and ECD measurements. In addition, the monoamine oxidase-A (MAO-A), MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Alkaloids 1-3 inhibited the MAO-A activity with IC50 values of 1.4, 1.4, and 0.9 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azepinas / Alcaloides Indólicos / Psychotria Idioma: En Revista: J Nat Prod Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azepinas / Alcaloides Indólicos / Psychotria Idioma: En Revista: J Nat Prod Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos