Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi-Substituted &#916;<sup>2</sup> -Pyrrolines and Their Cytotoxicity.

Anil, Seegehalli M; Sudhanva, Muddenahalli S; Swaroop, Toreshettahally R; Vinayaka, Ajjampura C; Rajeev, Narasimhamurthy; Kiran, Kuppalli R; Shobith, Rangappa; Sadashiva, Maralinganadoddi P

Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi-Substituted Δ² -Pyrrolines and Their Cytotoxicity.

Anil, Seegehalli M; Sudhanva, Muddenahalli S; Swaroop, Toreshettahally R; Vinayaka, Ajjampura C; Rajeev, Narasimhamurthy; Kiran, Kuppalli R; Shobith, Rangappa; Sadashiva, Maralinganadoddi P.

Afiliación

Anil SM; Institute of Plant Science, ARO, Volcani Center, Rishon LeZion, 7505101, Israel.
Sudhanva MS; Adichunchanagiri Institute for Molecular Medicine, Nagamangala, Karnataka, 571448, India.
Swaroop TR; Department of Studies in Organic Chemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, 570006, India.
Vinayaka AC; Institute of Plant Science, ARO, Volcani Center, Rishon LeZion, 7505101, Israel.
Rajeev N; Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, 570006, India.
Kiran KR; Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, 570006, India.
Shobith R; Adichunchanagiri Institute for Molecular Medicine, Nagamangala, Karnataka, 571448, India.
Sadashiva MP; Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, 570006, India.

Chem Biodivers ; 17(5): e2000014, 2020 May.

Article en En | MEDLINE | ID: mdl-32147970

Asunto(s)

Antineoplásicos/farmacología; Lactonas/farmacología; Nitrilos/farmacología; Pirroles/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Lactonas/química; Estructura Molecular; Nitrilos/química; Pirroles/síntesis química; Pirroles/química; Relación Estructura-Actividad

Palabras clave

1,2-addition reaction; Erlenmeyer azlactones; cytotoxicity; pyrrolines, condensation reaction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirroles / Lactonas / Antineoplásicos / Nitrilos Límite: Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Suiza

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