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Zinc Oxide Particles Catalytically Generate Nitric Oxide from Endogenous and Exogenous Prodrugs.
Yang, Tao; Fruergaard, Anne Sofie; Winther, Anna K; Zelikin, Alexander N; Chandrawati, Rona.
Afiliación
  • Yang T; School of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales (UNSW Sydney), Sydney, NSW, 2052, Australia.
  • Fruergaard AS; Department of Chemistry and iNANO Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, C 8000, Denmark.
  • Winther AK; Department of Chemistry and iNANO Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, C 8000, Denmark.
  • Zelikin AN; Department of Chemistry and iNANO Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, C 8000, Denmark.
  • Chandrawati R; School of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales (UNSW Sydney), Sydney, NSW, 2052, Australia.
Small ; 16(27): e1906744, 2020 07.
Article en En | MEDLINE | ID: mdl-32141238
Nitric oxide (NO) is a potent biological molecule that contributes to a wide spectrum of physiological processes. However, the full potential of NO as a therapeutic agent is significantly complicated by its short half-life and limited diffusion distance in human tissues. Current strategies for NO delivery focus on encapsulation of NO donors into prefabricated scaffolds or an enzyme-prodrug therapy approach. The former is limited by the finite pool of NO donors available, while the latter is challenged by the inherent low stability of natural enzymes. Zinc oxide (ZnO) particles with innate glutathione peroxidase and glycosidase activities, a combination that allows to catalytically decompose both endogenous (S-nitrosoglutathione) and exogenous (ß-gal-NONOate) donors to generate NO at physiological conditions are reported. By tuning the concentration of ZnO particles and NO prodrugs, physiologically relevant NO levels are achieved. ZnO preserves its catalytic property for at least 6 months and the activity of ZnO in generating NO from prodrugs in human serum is demonstrated. The ZnO catalytic activity will be beneficial toward generating stable NO release for long-term biomedical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Profármacos / Tecnología Biomédica / Óxido Nítrico Límite: Humans Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Profármacos / Tecnología Biomédica / Óxido Nítrico Límite: Humans Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania