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Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices.
Wu, Yuanhao; Okesola, Babatunde O; Xu, Jing; Korotkin, Ivan; Berardo, Alice; Corridori, Ilaria; di Brocchetti, Francesco Luigi Pellerej; Kanczler, Janos; Feng, Jingyu; Li, Weiqi; Shi, Yejiao; Farafonov, Vladimir; Wang, Yiqiang; Thompson, Rebecca F; Titirici, Maria-Magdalena; Nerukh, Dmitry; Karabasov, Sergey; Oreffo, Richard O C; Carlos Rodriguez-Cabello, Jose; Vozzi, Giovanni; Azevedo, Helena S; Pugno, Nicola M; Wang, Wen; Mata, Alvaro.
Afiliación
  • Wu Y; Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
  • Okesola BO; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Xu J; School of Pharmacy, University of Nottingham, NG7 2RD, Nottingham, UK.
  • Korotkin I; Department of Chemical and Environmental Engineering, University of Nottingham, NG7 2RD, Nottingham, UK.
  • Berardo A; Biodiscovery Institute, University of Nottingham, NG7 2RD, Nottingham, UK.
  • Corridori I; Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
  • di Brocchetti FLP; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Kanczler J; Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
  • Feng J; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Li W; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Shi Y; Mathematical Sciences, University of Southampton, Southampton SO17 1BJ, UK.
  • Farafonov V; Laboratory of Bio-inspired, Bionic, Nano, Meta Materials & Mechanics, Università di Trento, via Mesiano, 77, I-38123, Trento, Italy.
  • Wang Y; C3A - Center Agriculture Food Environment, University of Trento/Fondazione Edmund Mach, Via Edmund Mach, 1 - 38010, San Michele all'Adige (TN), Italy.
  • Thompson RF; Laboratory of Bio-inspired, Bionic, Nano, Meta Materials & Mechanics, Università di Trento, via Mesiano, 77, I-38123, Trento, Italy.
  • Titirici MM; Research Center'E. Piaggio' & Dipartimento di Ingegneria dell'Informazione, University of Pisa, Largo Lucio Lazzarino, 256126, Pisa, Italy.
  • Nerukh D; Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
  • Karabasov S; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Oreffo ROC; Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
  • Carlos Rodriguez-Cabello J; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Vozzi G; Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
  • Azevedo HS; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Pugno NM; Department of Physical Chemistry, V. N. Karazin Kharkiv National University, Svobody Sq. 4, Kharkiv, 61022, Ukraine.
  • Wang W; United Kingdom Atomic Energy Authority, Culham Science Centre, Abingdon, OX14 3DB, UK.
  • Mata A; The Astbury Biostructure Laboratory, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Nat Commun ; 11(1): 1182, 2020 03 04.
Article en En | MEDLINE | ID: mdl-32132534
Supramolecular chemistry offers an exciting opportunity to assemble materials with molecular precision. However, there remains an unmet need to turn molecular self-assembly into functional materials and devices. Harnessing the inherent properties of both disordered proteins and graphene oxide (GO), we report a disordered protein-GO co-assembling system that through a diffusion-reaction process and disorder-to-order transitions generates hierarchically organized materials that exhibit high stability and access to non-equilibrium on demand. We use experimental approaches and molecular dynamics simulations to describe the underlying molecular mechanism of formation and establish key rules for its design and regulation. Through rapid prototyping techniques, we demonstrate the system's capacity to be controlled with spatio-temporal precision into well-defined capillary-like fluidic microstructures with a high level of biocompatibility and, importantly, the capacity to withstand flow. Our study presents an innovative approach to transform rational supramolecular design into functional engineering with potential widespread use in microfluidic systems and organ-on-a-chip platforms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Equipo / Proteína Elk-1 con Dominio ets / Dispositivos Laboratorio en un Chip / Bioimpresión / Grafito Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Equipo / Proteína Elk-1 con Dominio ets / Dispositivos Laboratorio en un Chip / Bioimpresión / Grafito Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido