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Hearing loss is associated with cortical thinning in cognitively normal older adults.
Ha, J; Cho, Y S; Kim, S J; Cho, S H; Kim, J P; Jung, Y H; Jang, H; Shin, H-Y; Lin, F R; Na, D L; Seo, S W; Moon, I J; Kim, H J.
Afiliación
  • Ha J; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Cho YS; Samsung Alzheimer Research Center, Samsung Medical Center, Seoul, Korea.
  • Kim SJ; Neuroscience Center, Samsung Medical Center, Seoul, Korea.
  • Cho SH; Department of Otolaryngology - Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Kim JP; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Jung YH; Samsung Alzheimer Research Center, Samsung Medical Center, Seoul, Korea.
  • Jang H; Neuroscience Center, Samsung Medical Center, Seoul, Korea.
  • Shin HY; Department of Neurology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon, Korea.
  • Lin FR; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Na DL; Samsung Alzheimer Research Center, Samsung Medical Center, Seoul, Korea.
  • Seo SW; Neuroscience Center, Samsung Medical Center, Seoul, Korea.
  • Moon IJ; Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
  • Kim HJ; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Eur J Neurol ; 27(6): 1003-1009, 2020 06.
Article en En | MEDLINE | ID: mdl-32125747
BACKGROUND AND PURPOSE: Hearing loss (HL) is one of the most influential risk factors of dementia in older adults. However, its potential association with neurodegeneration is not well established. The association between HL and cortical thickness in cognitively normal older adults was evaluated. METHODS: In all, 982 cognitively normal older adults (age ≥65 years) were identified from the Health Promotion Center at the Samsung Medical Center from September 2008 to December 2014. The participants underwent pure-tone audiometry and brain magnetic resonance imaging. HL was evaluated according to a four-frequency (0.5, 1, 2, 4 kHz) pure-tone average. Participants were divided into three groups according to pure-tone average (normal hearing ≤15 dB, minimal HL 16-25 dB, mild-to-severe HL >25 dB). Cortical thickness in the HL groups was compared with that of the normal hearing group. RESULTS: In women, right ear HL was associated with cortical thinning: the minimal HL group showed cortical thinning in the left frontal and bilateral occipital areas and the mild-to-severe HL group showed cortical thinning in the bilateral frontal, right temporal and bilateral occipital areas compared to the normal hearing group. In men, there was no significant association between HL on either side and cortical thickness. CONCLUSION: In older women, right ear HL is associated with neurodegeneration even in a cognitively normal state. Therefore, managing HL especially in older women may be an effective strategy for dementia prevention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adelgazamiento de la Corteza Cerebral / Pérdida Auditiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adelgazamiento de la Corteza Cerebral / Pérdida Auditiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido