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Sodium Butyrate Downregulates Implant-Induced Inflammation in Mice.
de Lazari, Marcela Guimarães Takahashi; Pereira, Luciana Xavier; Orellano, Laura Alejandra Ariza; Scheuermann, Karina; Machado, Clara Tolentino; Vasconcelos, Anilton Cesar; Andrade, Silvia Passos; Campos, Paula Peixoto.
Afiliación
  • de Lazari MGT; Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
  • Pereira LX; Laboratório de Histopatologia, Universidade Federal de Alagoas - Campus Arapiraca, Arapiraca, Brazil.
  • Orellano LAA; Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
  • Scheuermann K; Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
  • Machado CT; Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
  • Vasconcelos AC; Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
  • Andrade SP; Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Campos PP; Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627 - Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil. paulapc@icb.ufmg.br.
Inflammation ; 43(4): 1259-1268, 2020 Aug.
Article en En | MEDLINE | ID: mdl-32125592
Sodium butyrate (NaBu), a histone deacetylase inhibitor, has shown to exert beneficial actions attenuating inflammation in a number of intestinal and extra-intestinal diseases. However, the effects of NaBu on persistent inflammatory processes as in a response to implantation of foreign material have not been investigated. Synthetic matrix of polyether-polyurethane sponge was implanted in mice's subcutaneous layer of the dorsal region, and the animals were treated daily with oral administration of NaBu (100 mg/kg). After 7 days, the implants were removed and processed for assessment of inflammatory markers. Butyrate treatment caused a significant attenuation of neutrophil and macrophage infiltration in implants, which was reflected by the reduction of myeloperoxidase and N-acetyl-ß-D-glucosaminidase activities, respectively. Similar reduction was observed in intra-implants nitrite levels of NaBu-treated mice. NaBu treatment was also able to decrease mast cell recruitment/activation and the levels of CXCL1, CCL2, IL-6, TNF-ɑ, and TGF-ß1 in the implants but did not alter the levels of IL-10. In addition, NaBu administration decreased the concentration of proteins p65 and p50 in the nucleus as compared with the cytoplasm by western blot analysis. This result suggests that treatment with NaBu inhibited the NF-κB pathway. The circulating levels of TNF-ɑ and TGF-ß1 were also attenuated by NaBu. Persistent inflammation at sites of implanted devices very often impairs their functionality; therefore, our findings suggest that NaBu holds potential therapeutic value to control this adverse response to biomedical implants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis e Implantes / Regulación hacia Abajo / Mediadores de Inflamación / Ácido Butírico / Antagonistas de los Receptores Histamínicos Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Inflammation Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis e Implantes / Regulación hacia Abajo / Mediadores de Inflamación / Ácido Butírico / Antagonistas de los Receptores Histamínicos Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Inflammation Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos