Your browser doesn't support javascript.
loading
Brain metastases treated with radiosurgery or hypofractionated stereotactic radiotherapy: outcomes and predictors of survival.
Sallabanda, M; García-Berrocal, M I; Romero, J; García-Jarabo, V; Expósito, M J; Rincón, D F; Zapata, I; Magallón, M R.
Afiliación
  • Sallabanda M; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain. msallabanda@gmail.com.
  • García-Berrocal MI; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain.
  • Romero J; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain.
  • García-Jarabo V; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain.
  • Expósito MJ; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain.
  • Rincón DF; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain.
  • Zapata I; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain.
  • Magallón MR; Radiation Oncology Department, Hospital Puerta de Hierro Majadahonda, Calle Manuel de Falla N.1, Majadahonda, CP. 28222, Madrid, Spain.
Clin Transl Oncol ; 22(10): 1809-1817, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32124243
INTRODUCTION: To assess treatment outcome and prognostic factors associated with prolonged survival in patients with brain metastases (BM) treated with stereotactic radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (HFSRT). METHODS/PATIENTS: This study retrospectively reviewed 200 patients with 324 BM treated with one fraction (15-21 Gy) or 5-10 fractions (25-40 Gy) between January 2010 and August 2016. 26.5% of patients received whole brain radiotherapy (WBRT) and 25% initial surgery. Demographics, prognostic scales, systemic and local controls, patterns of relapse and rescue, toxicity, and cause of death were analyzed. A stratified analysis by primary tumor was done. RESULTS: Median overall survival (OS) was 8 months from SRS/HFSRT. Breast cancer patients had a median OS of 17 months, followed by renal (11 months), lung (8 months), colorectal (5 months), and melanoma (4 months). The univariate analysis showed improved OS in females (p 0.004), RPA I-II (p < 0.001) initial surgery (p < 0.001), absence of extracranial disease (p 0.023), and good disease control (p 0.002). There were no differences in OS or local control between SRS and HFSRT or in patients receiving WBRT. Among 44% of brain recurrences, 11% were in field. 174 patients died, 10% from confirmed intracranial progression. CONCLUSIONS: SRS and HSFRT are equally effective and safe for the treatment of BM, with no exceptions among different primary tumors. Disease control, surgery, age, and prognostic scales correlated with OS. However, the lack of survival benefit regarding WBRT might become logical evidence for its omission in a subset of patients.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Radiocirugia / Hipofraccionamiento de la Dosis de Radiación Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Radiocirugia / Hipofraccionamiento de la Dosis de Radiación Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia