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Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).
Altonsy, Mohammed O; Ganguly, Anutosh; Amrein, Matthias; Surmanowicz, Philip; Li, Shu Shun; Lauzon, Gilles J; Mydlarski, P Régine.
Afiliación
  • Altonsy MO; Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB T2T 5C7, Canada.
  • Ganguly A; Department of Zoology, Faculty of Science, Sohag University, 82524 Sohag, Egypt.
  • Amrein M; Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB T2T 5C7, Canada.
  • Surmanowicz P; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada.
  • Li SS; Department of Surgery, University of Michigan, Ann Arbor, Michigan, MI 48105, USA.
  • Lauzon GJ; Department of Cell Biology and Anatomy, University of Calgary, Calgary, AB T2N 4N1, Canada.
  • Mydlarski PR; Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB T2T 5C7, Canada.
Int J Mol Sci ; 21(5)2020 Feb 28.
Article en En | MEDLINE | ID: mdl-32121295
Microtubules (MTs), microfilaments, and intermediate filaments, the main constituents of the cytoskeleton, undergo continuous structural changes (metamorphosis), which are central to cellular growth, division, and release of microvesicles (MVs). Altered MTs dynamics, uncontrolled proliferation, and increased production of MVs are hallmarks of carcinogenesis. Class III beta-tubulin (ß3-tubulin), one of seven ß-tubulin isotypes, is a primary component of MT, which correlates with enhanced neoplastic cell survival, metastasis and resistance to chemotherapy. We studied the effects of ß3-tubulin gene silencing on MTs dynamics, cell cycle, and MVs release in human malignant melanoma cells (A375). The knockdown of ß3-tubulin induced G2/M cell cycle arrest, impaired MTs dynamics, and reduced spontaneous MVs release. Additional studies are therefore required to elucidate the pathophysiologic and therapeutic role of ß3-tubulin in melanoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Ciclo Celular / Micropartículas Derivadas de Células / Melanoma / Microtúbulos Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Ciclo Celular / Micropartículas Derivadas de Células / Melanoma / Microtúbulos Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza