[Preparation and testing of polymer drugs. 3. Binding of benzocaine to polyacrylic acid with a spacer]. / Darstellung und Testung von Polymerpharmaka. 3. Mitteilung: Bindung von Benzocain über einen Spacer an Polyacrylsäure.
Pharmazie
; 43(10): 692-3, 1988 Oct.
Article
en De
| MEDLINE
| ID: mdl-3212014
epsilon-Aminocapronic acid (1) as spacer was introduced in polymeric drugs on the basis of polyacrylic acid. Benzocain served as model drug. Polymeric drugs were synthesized by copolymerisation with free acrylic acid. Not all functional groups of the carrier reacted with the model drug. This product showed a strong swelling during the release of the covalently bound drugs. Pancreatin was used for this investigation. A raising of the splitting rate was achieved by incorporation of the spacer in the polymeric drugs. However, the low rate of cleaving is not relevant for practical use.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzocaína
Idioma:
De
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
1988
Tipo del documento:
Article
Pais de publicación:
Alemania