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Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement.
Zborníková, Eva; Gallo, Jirí; Vecerová, Renata; Bogdanová, Katerina; Kolár, Milan; Vítovská, Dragana; Do Pham, Duy Dinh; Paces, Ondrej; Mojr, Viktor; Sanderová, Hana; Ulrichová, Jitka; Galandáková, Adéla; Cadek, Drahomír; Hrdlicka, Zdenek; Krásný, Libor; Rejman, Dominik.
Afiliación
  • Zborníková E; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Gallo J; Department of Analytical Chemistry, Faculty of Science, Charles University Prague, Hlavova 8, 128 43 Prague 2, Czech Republic.
  • Vecerová R; Department of Orthopedics, Faculty of Medicine and Dentistry, Palacký University Olomouc, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic.
  • Bogdanová K; Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
  • Kolár M; Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
  • Vítovská D; Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
  • Do Pham DD; Institute of Microbiology, Czech Academy of Sciences v.v.i., Vídenská 1083, 142 20 Prague 4, Czech Republic.
  • Paces O; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Mojr V; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Sanderová H; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Ulrichová J; Institute of Microbiology, Czech Academy of Sciences v.v.i., Vídenská 1083, 142 20 Prague 4, Czech Republic.
  • Galandáková A; Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
  • Cadek D; Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
  • Hrdlicka Z; Department of Polymers, University of Chemistry and Technology Prague, Technická 5, Dejvice, 166 28 Praha 6, Czech Republic.
  • Krásný L; Department of Polymers, University of Chemistry and Technology Prague, Technická 5, Dejvice, 166 28 Praha 6, Czech Republic.
  • Rejman D; Institute of Microbiology, Czech Academy of Sciences v.v.i., Vídenská 1083, 142 20 Prague 4, Czech Republic.
ACS Omega ; 5(7): 3165-3171, 2020 Feb 25.
Article en En | MEDLINE | ID: mdl-32118132
Successful surgeries involving orthopedic implants depend on the avoidance of biofilm development on the implant surface during the early postoperative period. Here, we investigate the potential of novel antibacterial compounds-second-generation lipophosphonoxins (LPPOs II)-as additives to surgical bone cements. We demonstrate (i) excellent thermostability of LPPOs II, which is essential to withstand elevated temperatures during exothermic cement polymerization; (ii) unchanged tensile strength and elongation at the break properties of the composite cements containing LPPOs II compared to cements without additives; (iii) convenient elution kinetics on the order of days; and (iv) the strong antibiofilm activity of the LPPO II-loaded cements even against bacteria resistant to the medicinally utilized antibiotic, gentamicin. Thus, LPPOs II display promising potential as antimicrobial additives to surgical bone cements.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2020 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2020 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos