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Treatment outcomes of adjunctive teriparatide therapy for medication-related osteonecrosis of the jaw (MRONJ): A multicenter retrospective analysis in Japan.
Morishita, Kota; Yamada, Shin-Ichi; Kawakita, Akiko; Hashidume, Masao; Tachibana, Akira; Takeuchi, Noritami; Ohbayashi, Yumiko; Kanno, Takahiro; Yoshiga, Daigo; Narai, Takashi; Sasaki, Noboru; Shinohara, Hisayuki; Uzawa, Narikazu; Miyake, Minoru; Tominaga, Kazuhiro; Kodani, Isamu; Umeda, Masahiro; Kurita, Hiroshi.
Afiliación
  • Morishita K; Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan; Department of Clinical Oral Oncology, Unit of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sa
  • Yamada SI; Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan. Electronic address: yshinshin@shinshu-u.ac.jp.
  • Kawakita A; Department of Clinical Oral Oncology, Unit of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
  • Hashidume M; Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan.
  • Tachibana A; Department of Oral Maxillofacial Surgery, Kakogawa Central City Hospital, 439, Honmachi, Kakogawa-cho, Kakogawa, 675-8611, Japan.
  • Takeuchi N; Department of Oral and Maxillofacial Surgery, Matsubara Tokushukai Hospital, 7-13-26, Amamihigashi, Matsubara, 580-0032, Japan.
  • Ohbayashi Y; Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
  • Kanno T; Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, 89-1 Enyacho, Izumo, 693-8501, Japan.
  • Yoshiga D; Department of Science of Physical Function, Division of Oral Medicine, Kyushu Dental University, 2-6-1, Manazuru, Kokura-kita, Kitakyushu, 803-8580, Japan.
  • Narai T; Department of Medicine of Sensory and Motor Organs, Division of Oral and Maxillofacial Surgery, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
  • Sasaki N; Dentistry, Oral and Maxillofacial Surgery, Amagasaki Chuo Hospital, 1-12-1, Shioe, Amagasaki, 661-0976, Japan.
  • Shinohara H; Hokuryu established by the town dentist's office, 2-17, Azayawara, Hokuryu, 078-2512, Japan.
  • Uzawa N; Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka Suita, Osaka, 565-0871, Japan.
  • Miyake M; Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
  • Tominaga K; Department of Science of Physical Functions, Division of Oral and Maxillofacial Surgery, Kyushu Dental University, 2-6-1, Manazuru, Kokura-kita, Kitakyushu, 803-8580, Japan.
  • Kodani I; Department of Medicine of Sensory and Motor Organs, Division of Oral and Maxillofacial Surgery, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
  • Umeda M; Department of Clinical Oral Oncology, Unit of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
  • Kurita H; Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan.
J Orthop Sci ; 25(6): 1079-1083, 2020 Nov.
Article en En | MEDLINE | ID: mdl-32111549
BACKGROUND: Therapeutic strategies for patients with medication-related osteonecrosis of the jaw (MRONJ) remain controversial. The aim of the present study was to clarify the effectiveness and safety of teriparatide therapy in Japanese MRONJ patients based on a large number of case series with a multicenter retrospective analysis. PATIENTS AND METHODS: Between January 2012 and December 2016, 29 patients who were diagnosed with MRONJ at 10 hospitals were treated with teriparatide. The medical records of these patients were retrospectively reviewed to assess the efficacy and safety of teriparatide therapy for MRONJ patients. RESULTS: Adverse events occurred in 17.2% of patients (5/29). One patient developed severe arthralgia and discontinued teriparatide therapy after 12 days, while others continued the treatment. Among 29 patients, the median period of administration of teriparatide was 14.0 months (range, 0.3-26 months), and treatment outcomes were evaluated as effective in 75.9% of patients with complete resolution in 65.5%. Among patients treated with oral bisphosphonates (BPs), 83.3% were effectively treated with teriparatide and 40% with intravenous BPs. The oral administration of BPs was associated with successful treatment outcomes with teriparatide (p = 0.062). CONCLUSIONS: Teriparatide therapy has potential as an effective treatment option for MRONJ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conservadores de la Densidad Ósea / Osteonecrosis de los Maxilares Asociada a Difosfonatos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: J Orthop Sci Asunto de la revista: ORTOPEDIA Año: 2020 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conservadores de la Densidad Ósea / Osteonecrosis de los Maxilares Asociada a Difosfonatos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: J Orthop Sci Asunto de la revista: ORTOPEDIA Año: 2020 Tipo del documento: Article Pais de publicación: Japón