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Socioeconomic characteristics of women with substance use disorder during pregnancy and neonatal outcomes in their newborns: A national registry study from the Czech Republic.
Mravcík, Viktor; Nechanská, Blanka; Gabrhelík, Roman; Handal, Marte; Mahic, Milada; Skurtveit, Svetlana.
Afiliación
  • Mravcík V; Department of Addictology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; National Monitoring Centre for Drugs and Addiction, Office of the Government, Prague, Czech Republic. Electronic address: viktor.mravcik@lf1.cuni.cz.
  • Nechanská B; Department of Addictology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic.
  • Gabrhelík R; Department of Addictology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Handal M; Norwegian Institute of Public Health, Oslo, Norway.
  • Mahic M; Norwegian Institute of Public Health, Oslo, Norway.
  • Skurtveit S; Norwegian Institute of Public Health, Oslo, Norway; Norwegian Centre for Addiction Research at the University of Oslo, Norway.
Drug Alcohol Depend ; 209: 107933, 2020 04 01.
Article en En | MEDLINE | ID: mdl-32109712
BACKGROUND: Maternal substance use can pose a risk to the fetal health. We studied the background characteristics of women with substance use disorders (SUDs) and selected neonatal outcomes in their children. MATERIAL AND METHODS: A database-linkage study was performed. The sample consisted of pregnant women with a SUD during pregnancy (ICD-10 diagnosis F10-F19 except F17, n = 1710), women not diagnosed with a SUD (n = 1,511,310) in Czechia in 2000-2014, and their children. The monitored neonatal outcomes were gestational age, birth weight, preterm birth, and small-for-gestational age (SGA). Binary logistic regression adjusted for age, marital status, education, concurrent substance use, and prenatal care was performed. RESULTS: Women with illicit SUDs were younger, more often unmarried, with a lower level of education, a higher abortion rate, a higher smoking rate, and lower compliance to prenatal care than women with a SUD related to alcohol, or sedatives and hypnotics (SH). Women with a SUD had worse socioeconomic situations, poorer pregnancy care, and worse neonatal outcomes than women without a SUD. After adjustment, we found no difference in SGA between the illicit SUD groups and the alcohol and the SH groups. The newborns from all SUD groups had a higher risk of SGA when compared to women without a SUD. However after adjustment, the difference remained significant just in the alcohol group (OR = 1.9, 95 % CI = 1.4-2.6). CONCLUSION: Mother's SUD during pregnancy increased risk of fetal growth restriction as measured by SGA. The role of maternal socioeconomic and lifestyle factors for the risk of SGA was substantial.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Factores Socioeconómicos / Resultado del Embarazo / Sistema de Registros / Trastornos Relacionados con Sustancias / Retardo del Crecimiento Fetal Tipo de estudio: Etiology_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Child / Female / Humans / Newborn / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Drug Alcohol Depend Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Factores Socioeconómicos / Resultado del Embarazo / Sistema de Registros / Trastornos Relacionados con Sustancias / Retardo del Crecimiento Fetal Tipo de estudio: Etiology_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Child / Female / Humans / Newborn / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Drug Alcohol Depend Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda