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Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice.
Danish, Lubna; Siddiq, Riffat; Jahan, Sarwat; Taneez, Mehwish; Khan, Manzoor; Sandhu, Marva.
Afiliación
  • Danish L; Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS), International Islamic University Islamabad (IIUI), Islamabad, Pakistan.
  • Siddiq R; Department of Maxillofacial Surgery, Rehman College of Dentistry, Peshawar, Pakistan.
  • Jahan S; Northwest School of Medicine, Phase-V Hayatabad, Peshawar, Pakistan.
  • Taneez M; Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS), International Islamic University Islamabad (IIUI), Islamabad, Pakistan.
  • Khan M; Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.
  • Sandhu M; Department of Pharmacology, National Institute of Health (NIH), Islamabad, Pakistan.
Int J Hepatol ; 2020: 9185361, 2020.
Article en En | MEDLINE | ID: mdl-32099681
Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Hepatol Año: 2020 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Hepatol Año: 2020 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos