Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A.

Lochhead, Marina R; Brown, Alexandra D; Kirlin, Alyssa C; Chitayat, Seth; Munro, Kim; Findlay, Jane E; Baillie, George S; LeBrun, David P; Langelaan, David N; Smith, Steven P

Lochhead, Marina R; Brown, Alexandra D; Kirlin, Alyssa C; Chitayat, Seth; Munro, Kim; Findlay, Jane E; Baillie, George S; LeBrun, David P; Langelaan, David N; Smith, Steven P.

Afiliación

Lochhead MR; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Brown AD; Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Kirlin AC; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Chitayat S; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Munro K; Protein Function Discovery Group, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Findlay JE; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
Baillie GS; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
LeBrun DP; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Langelaan DN; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada; Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: david.langelaan@dal.ca.
Smith SP; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada; Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: steven.smith@queensu.ca.

J Biol Chem ; 295(13): 4303-4315, 2020 03 27.

Article en En | MEDLINE | ID: mdl-32098872

Asunto(s)

Proteína de Unión a CREB/química; Proteína p300 Asociada a E1A/genética; Dominios Proteicos/genética; Factor de Transcripción 3/química; Linfocitos B/química; Linfocitos B/metabolismo; Proteína de Unión a CREB/genética; Proteína de Unión a CREB/ultraestructura; Proteína p300 Asociada a E1A/química; Proteína p300 Asociada a E1A/ultraestructura; Proteínas de Homeodominio/química; Proteínas de Homeodominio/genética; Proteínas de Homeodominio/ultraestructura; Humanos; Mutación/genética; Proteínas de Fusión Oncogénica/química; Proteínas de Fusión Oncogénica/genética; Proteínas de Fusión Oncogénica/ultraestructura; Unión Proteica/genética; Conformación Proteica; Factor de Transcripción 3/genética; Factor de Transcripción 3/ultraestructura

Palabras clave

E1A-binding protein p300 (P300); TAZ2 domain; basic helix-loop-helix transcription factor (bHLH); hematopoiesis; intrinsically disordered protein; isothermal titration calorimetry (ITC); lymphocyte; nuclear magnetic resonance (NMR); protein structure; protein-protein interaction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína de Unión a CREB / Proteína p300 Asociada a E1A / Factor de Transcripción 3 / Dominios Proteicos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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