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A metal-phenolic network-based multifunctional nanocomposite with pH-responsive ROS generation and drug release for synergistic chemodynamic/photothermal/chemo-therapy.
Meng, Xiangyu; Chen, Lizhu; Lv, Rongmu; Liu, Mei; He, Nongyue; Wang, Zhifei.
Afiliación
  • Meng X; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, Jiangsu, P. R. China. zfwang@seu.edu.cn.
  • Chen L; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, Jiangsu, P. R. China. zfwang@seu.edu.cn.
  • Lv R; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, Jiangsu, P. R. China. zfwang@seu.edu.cn.
  • Liu M; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, Jiangsu, P. R. China. zfwang@seu.edu.cn.
  • He N; State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education (Southeast University), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, Jiangsu, P. R. China.
  • Wang Z; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, Jiangsu, P. R. China. zfwang@seu.edu.cn.
J Mater Chem B ; 8(10): 2177-2188, 2020 03 14.
Article en En | MEDLINE | ID: mdl-32096524
Developing multifunctional nanomaterials with chemodynamic therapy (CDT)-based combination therapy has increasingly become a promising strategy for cancer treatment. Herein, a metal-phenolic network-based multifunctional nanocomposite (PID@Fe-TA) via the noncovalent interaction of multiple nontoxic raw materials has been designed to integrate the synergistic effect of CDT, photothermal therapy (PTT) and chemotherapy into one nanoplatform for breast cancer treatment. Benefiting from the pH-responsive properties and the assistance of near infrared (NIR) laser irradiation, the outer shell Fe3+-tannic acid (TA) complexes of PID@Fe-TA can be easily degraded into Fe3+ and TA as well as to release chemotherapeutic drugs (doxorubicin, DOX) and photothermal transforming agents (indocyanine green, ICG) in a tumor microenvironment (TME) or cancer cells. The released TA can accelerate the reduction of Fe3+ to Fe2+ for ensuring effective conversion of hydrogen peroxide (H2O2) into a highly toxic hydroxyl radical (˙OH) via the Fenton reaction. The exposed DOX can enter the cell nucleus to induce chemotherapy. The released ICG can locate the distribution of nanocomposites in the body. Besides, the heat generated from PID@Fe-TA after NIR laser irradiation can further promote the therapeutic effect of PPT-enhanced CDT. Importantly, an excellent therapeutic efficacy is achieved both in in vitro and in vivo via the CDT/PTT/chemotherapy combination based on this "all-in-one" nanoplatform, providing a good paradigm for effective cancer eradication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Sistemas de Liberación de Medicamentos / Especies Reactivas de Oxígeno / Terapia Combinada / Nanocompuestos / Liberación de Fármacos Límite: Humans Idioma: En Revista: J Mater Chem B Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Sistemas de Liberación de Medicamentos / Especies Reactivas de Oxígeno / Terapia Combinada / Nanocompuestos / Liberación de Fármacos Límite: Humans Idioma: En Revista: J Mater Chem B Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido